Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer’s disease associated with inflammasome activation and ASC speck propagation

Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer’s disease associated with inflammasome activation and ASC speck propagation

Abstract Background Alcohol use disorder (AUD) has been associated with Alzheimer’s disease (AD) and dementia, yet the underlying mechanisms and specific role of ethanol in AD progression remain poorly understood. Neuroinflammation has emerged as a key contributor to both AD pathogenesis and ethanol...

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Main Authors: Veronika Brezani, Radhika S. Joshi, Marti Ortega-Ribera, Prashanth Thevkar Nagesh, Viliam Brezani, Adam Zivny, Evelyn A. Kurt-Jones, Douglas T. Golenbock, Gyongyi Szabo
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s
Alcohol use disorder
Ethanol
Neuroinflammation
Inflammasome
ASC specks
Online Access:https://doi.org/10.1186/s12974-025-03501-8
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