Aging increases susceptibility to liver fibrosis through enhanced NAT10-mediated ac4C modification of TGFβ1 mRNA

Aging increases susceptibility to liver fibrosis through enhanced NAT10-mediated ac4C modification of TGFβ1 mRNA

Abstract Background The epidemiological observational studies unveiled that aging is one of the risk factors for liver fibrosis, and the hepatic tissues in the elderly harbor more fibrotic lesions when compared to those in young people. Previous investigations found that TGFβ1 was elevated with agin...

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Bibliographic Details
Main Authors: Xuyun Peng, Panlong Li, Ying Zhang, Qi Zhang, Weicheng Liang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Genome Medicine
Subjects:
Liver fibrosis
Aging
RNA modification
TGFβ/SMAD signaling pathway
NAT10
Online Access:https://doi.org/10.1186/s13073-025-01520-x
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