Systemic Sclerosis – A Diagnostic Challenge or a Clinically Controllable Disease?

Systemic sclerosis is a complex and heterogeneous autoimmune condition in which skin and internal organ involvement progresses through interrelated processes of vasculopathy, immune activation, and fibrosis. Although considered an uncommon disease, its impact is disproportionate due to delayed diag...

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Main Authors: Olga Kądziołka, Karolina Skonieczna, Magdalena Badziąg, Paulina Szulc, Laura Kurczoba, Martyna Kłossowska, Olimpia Wiciun, Kacper Ordon
Format: Article
Language:English
Published: Nicolaus Copernicus University in Toruń 2025-06-01
Series:Quality in Sport
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Online Access:https://apcz.umk.pl/QS/article/view/60484
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author Olga Kądziołka
Karolina Skonieczna
Magdalena Badziąg
Paulina Szulc
Laura Kurczoba
Martyna Kłossowska
Olimpia Wiciun
Kacper Ordon
author_facet Olga Kądziołka
Karolina Skonieczna
Magdalena Badziąg
Paulina Szulc
Laura Kurczoba
Martyna Kłossowska
Olimpia Wiciun
Kacper Ordon
author_sort Olga Kądziołka
collection DOAJ
description Systemic sclerosis is a complex and heterogeneous autoimmune condition in which skin and internal organ involvement progresses through interrelated processes of vasculopathy, immune activation, and fibrosis. Although considered an uncommon disease, its impact is disproportionate due to delayed diagnosis and potential for multiorgan complications. This review aims to synthesize current knowledge on the underlying mechanisms, clinical spectrum, and management strategies of systemic sclerosis, with particular attention to validated classification criteria and therapeutic recommendations. The paper emphasizes the role of early clinical suspicion, specific serologic and capillaroscopic findings, and the significance of evolving immunomodulatory and antifibrotic therapies. An individualized and multidisciplinary approach remains essential in improving patient outcomes and quality of life.
format Article
id doaj-art-4dd251ec852a42ceb2e61cf72b8a907e
institution OA Journals
issn 2450-3118
language English
publishDate 2025-06-01
publisher Nicolaus Copernicus University in Toruń
record_format Article
series Quality in Sport
spelling doaj-art-4dd251ec852a42ceb2e61cf72b8a907e2025-08-20T02:33:15ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-06-014210.12775/QS.2025.42.60484Systemic Sclerosis – A Diagnostic Challenge or a Clinically Controllable Disease?Olga Kądziołkahttps://orcid.org/0009-0006-1052-4504Karolina Skonieczna0https://orcid.org/0009-0009-0153-7444Magdalena Badziąghttps://orcid.org/0009-0008-8598-1034Paulina Szulchttps://orcid.org/0009-0007-7614-9214Laura Kurczobahttps://orcid.org/0009-0004-1330-991XMartyna Kłossowskahttps://orcid.org/0009-0002-7444-1637Olimpia Wiciunhttps://orcid.org/0009-0005-0318-5527Kacper Ordonhttps://orcid.org/0009-0000-1764-3422Uniwersytet Mikołaja Kopernika w Toruniu Systemic sclerosis is a complex and heterogeneous autoimmune condition in which skin and internal organ involvement progresses through interrelated processes of vasculopathy, immune activation, and fibrosis. Although considered an uncommon disease, its impact is disproportionate due to delayed diagnosis and potential for multiorgan complications. This review aims to synthesize current knowledge on the underlying mechanisms, clinical spectrum, and management strategies of systemic sclerosis, with particular attention to validated classification criteria and therapeutic recommendations. The paper emphasizes the role of early clinical suspicion, specific serologic and capillaroscopic findings, and the significance of evolving immunomodulatory and antifibrotic therapies. An individualized and multidisciplinary approach remains essential in improving patient outcomes and quality of life. https://apcz.umk.pl/QS/article/view/60484systemic sclerosissclerodermaautoimmunityvasculopathyfibrosisEULAR recommendations
spellingShingle Olga Kądziołka
Karolina Skonieczna
Magdalena Badziąg
Paulina Szulc
Laura Kurczoba
Martyna Kłossowska
Olimpia Wiciun
Kacper Ordon
Systemic Sclerosis – A Diagnostic Challenge or a Clinically Controllable Disease?
Quality in Sport
systemic sclerosis
scleroderma
autoimmunity
vasculopathy
fibrosis
EULAR recommendations
title Systemic Sclerosis – A Diagnostic Challenge or a Clinically Controllable Disease?
title_full Systemic Sclerosis – A Diagnostic Challenge or a Clinically Controllable Disease?
title_fullStr Systemic Sclerosis – A Diagnostic Challenge or a Clinically Controllable Disease?
title_full_unstemmed Systemic Sclerosis – A Diagnostic Challenge or a Clinically Controllable Disease?
title_short Systemic Sclerosis – A Diagnostic Challenge or a Clinically Controllable Disease?
title_sort systemic sclerosis a diagnostic challenge or a clinically controllable disease
topic systemic sclerosis
scleroderma
autoimmunity
vasculopathy
fibrosis
EULAR recommendations
url https://apcz.umk.pl/QS/article/view/60484
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AT karolinaskonieczna systemicsclerosisadiagnosticchallengeoraclinicallycontrollabledisease
AT magdalenabadziag systemicsclerosisadiagnosticchallengeoraclinicallycontrollabledisease
AT paulinaszulc systemicsclerosisadiagnosticchallengeoraclinicallycontrollabledisease
AT laurakurczoba systemicsclerosisadiagnosticchallengeoraclinicallycontrollabledisease
AT martynakłossowska systemicsclerosisadiagnosticchallengeoraclinicallycontrollabledisease
AT olimpiawiciun systemicsclerosisadiagnosticchallengeoraclinicallycontrollabledisease
AT kacperordon systemicsclerosisadiagnosticchallengeoraclinicallycontrollabledisease