LncRNA H19 promotes adipogenic differentiation disorder by sponging miR-130b-3p to upregulate PPARγ in steroid-induced osteonecrosis of the femoral head

LncRNA H19 promotes adipogenic differentiation disorder by sponging miR-130b-3p to upregulate PPARγ in steroid-induced osteonecrosis of the femoral head

Steroid-induced osteonecrosis of the femoral head (SONFH) is a debilitating condition linked to glucocorticoid-induced adipogenic dysregulation of bone marrow mesenchymal stem cells (BMSCs). While long noncoding RNA H19 has been implicated in differentiation disorders across pathologies, its role in...

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Bibliographic Details
Main Authors: Feifei Lin, Min Yi, Shicheng Zhou, Qingyu Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Genetics
Subjects:
steroid-induced osteonecrosis of the femoral head
H19
miR-130b-3p
PPARγ
bone marrow mesenchymal stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1529797/full
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