Intermittent hypoxia index: a new indicator for assessing the degree of intermittent hypoxia in obstructive sleep apnea
ObjectiveIn order to objectively and accurately evaluate the degree of nocturnal intermittent hypoxia (IH) in patients with obstructive sleep apnea (OSA), we developed the Newton quadrature low oxygen load assessment system (NLAS) to seek a new, quantifiable, comprehensive evaluation index of interm...
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Frontiers Media S.A.
2025-04-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1400376/full |
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| author | Kui Xie Xiaoqing Tang Jiacheng Zhou Xiang Liu Yunyun Zhang Xiaochuan Cui |
| author_facet | Kui Xie Xiaoqing Tang Jiacheng Zhou Xiang Liu Yunyun Zhang Xiaochuan Cui |
| author_sort | Kui Xie |
| collection | DOAJ |
| description | ObjectiveIn order to objectively and accurately evaluate the degree of nocturnal intermittent hypoxia (IH) in patients with obstructive sleep apnea (OSA), we developed the Newton quadrature low oxygen load assessment system (NLAS) to seek a new, quantifiable, comprehensive evaluation index of intermittent hypoxia (intermittent hypoxia index, IHI).MethodsDemographic characteristics, anthropometric measurements, and polysomnography (PSG) parameters [oxygen desaturation index (ODI), lowest oxygen saturation (LSpO2), time below 90% saturation (T90)] of 732 patients with OSA who underwent multi-channel sleep monitoring at the Sleep Center of Affiliated Wuxi People’s Hospital, Nanjing Medical University, from 2019 to 2023 were retrospectively collected. The IHI was calculated using the NLAS (Certificate of Registration Number for Computer Software Copyright of the People’s Republic of China: 12208933), and its threshold was defined. Additionally, correlation analysis was performed between IHI and T90, LSpO2, and ODI.ResultsAmong the 732 patients with OSA, IHI showed significant correlations with T90 (r = 0.922) and LSpO2 (r = 0.866), and moderate correlation with ODI (r = 0.675). The threshold for diagnosing hypoxia in OSA patients using IHI was 7.178 (%s/min).ConclusionThis study demonstrates that IHI calculated using NLAS covers various dimensions of IH indices in OSA patients undergoing multi-channel sleep monitoring. It correlates with parameters such as T90, LSpO2, and ODI. Independent of existing IH assessment indices, IHI holds promise as a new comprehensive assessment index for evaluating the degree of nocturnal IH in OSA. |
| format | Article |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-4dcd2da68f4b47bca48675d02a61d7162025-08-20T02:19:19ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-04-011210.3389/fmed.2025.14003761400376Intermittent hypoxia index: a new indicator for assessing the degree of intermittent hypoxia in obstructive sleep apneaKui Xie0Xiaoqing Tang1Jiacheng Zhou2Xiang Liu3Yunyun Zhang4Xiaochuan Cui5Department of General Practice and Sleep Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of General Practice and Sleep Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of General Practice and Sleep Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaAdvanced Information Materials Research Center, School of Physics and Materials Science, Guangzhou University, Guangzhou, ChinaDepartment of General Practice and Sleep Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of General Practice and Sleep Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaObjectiveIn order to objectively and accurately evaluate the degree of nocturnal intermittent hypoxia (IH) in patients with obstructive sleep apnea (OSA), we developed the Newton quadrature low oxygen load assessment system (NLAS) to seek a new, quantifiable, comprehensive evaluation index of intermittent hypoxia (intermittent hypoxia index, IHI).MethodsDemographic characteristics, anthropometric measurements, and polysomnography (PSG) parameters [oxygen desaturation index (ODI), lowest oxygen saturation (LSpO2), time below 90% saturation (T90)] of 732 patients with OSA who underwent multi-channel sleep monitoring at the Sleep Center of Affiliated Wuxi People’s Hospital, Nanjing Medical University, from 2019 to 2023 were retrospectively collected. The IHI was calculated using the NLAS (Certificate of Registration Number for Computer Software Copyright of the People’s Republic of China: 12208933), and its threshold was defined. Additionally, correlation analysis was performed between IHI and T90, LSpO2, and ODI.ResultsAmong the 732 patients with OSA, IHI showed significant correlations with T90 (r = 0.922) and LSpO2 (r = 0.866), and moderate correlation with ODI (r = 0.675). The threshold for diagnosing hypoxia in OSA patients using IHI was 7.178 (%s/min).ConclusionThis study demonstrates that IHI calculated using NLAS covers various dimensions of IH indices in OSA patients undergoing multi-channel sleep monitoring. It correlates with parameters such as T90, LSpO2, and ODI. Independent of existing IH assessment indices, IHI holds promise as a new comprehensive assessment index for evaluating the degree of nocturnal IH in OSA.https://www.frontiersin.org/articles/10.3389/fmed.2025.1400376/fullintermittent hypoxiaNewton quadrature low oxygen load assessment systemintermittent hypoxia indexobstructive sleep apneaNewton-cotes formula |
| spellingShingle | Kui Xie Xiaoqing Tang Jiacheng Zhou Xiang Liu Yunyun Zhang Xiaochuan Cui Intermittent hypoxia index: a new indicator for assessing the degree of intermittent hypoxia in obstructive sleep apnea Frontiers in Medicine intermittent hypoxia Newton quadrature low oxygen load assessment system intermittent hypoxia index obstructive sleep apnea Newton-cotes formula |
| title | Intermittent hypoxia index: a new indicator for assessing the degree of intermittent hypoxia in obstructive sleep apnea |
| title_full | Intermittent hypoxia index: a new indicator for assessing the degree of intermittent hypoxia in obstructive sleep apnea |
| title_fullStr | Intermittent hypoxia index: a new indicator for assessing the degree of intermittent hypoxia in obstructive sleep apnea |
| title_full_unstemmed | Intermittent hypoxia index: a new indicator for assessing the degree of intermittent hypoxia in obstructive sleep apnea |
| title_short | Intermittent hypoxia index: a new indicator for assessing the degree of intermittent hypoxia in obstructive sleep apnea |
| title_sort | intermittent hypoxia index a new indicator for assessing the degree of intermittent hypoxia in obstructive sleep apnea |
| topic | intermittent hypoxia Newton quadrature low oxygen load assessment system intermittent hypoxia index obstructive sleep apnea Newton-cotes formula |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1400376/full |
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