New opportunities for biomarkers in cardiovascular risk stratification. Resolution of Advisory board
Early detection of people with a high-risk of developing cardiovascular diseases is a key point of the prevention strategy. The existing risk scales have a number of limitations: insufficient accuracy for an individual or the appearance of a “residual risk”. Existing approaches to improving the accu...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2021-10-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4700 |
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| author | О. M. Drapkina A. V. on behalf of the working group Kontsevaya |
| author_facet | О. M. Drapkina A. V. on behalf of the working group Kontsevaya |
| author_sort | О. M. Drapkina |
| collection | DOAJ |
| description | Early detection of people with a high-risk of developing cardiovascular diseases is a key point of the prevention strategy. The existing risk scales have a number of limitations: insufficient accuracy for an individual or the appearance of a “residual risk”. Existing approaches to improving the accuracy of risk prediction include the use of biomarkers. Troponin I is promising, which has proven its prognostic value in healthy and asymptomatic individuals at the population level. For example, the BiomarCARE study with the participation of 74 thousand people from 5 countries showed an association of increased troponin I concentration and the frequency of cardiovascular events and overall mortality. Similar results were obtained in other cohorts. The simulation results indicate the potential economic feasibility of using troponin I for the purpose of risk stratification. The first pilot Russian study was conducted, which made it possible to describe the population distribution of troponin levels. It confirmed the prognostic significance of the biomarker in relation to the development of cardiovascular outcomes in men in the Russian population. Further studies on large cohorts are needed to clarify the results of the pilot project. |
| format | Article |
| id | doaj-art-4dcbd7cd92274130961bfd00e3d9ca82 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2021-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-4dcbd7cd92274130961bfd00e3d9ca822025-08-20T03:57:22Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202021-10-0126910.15829/1560-4071-2021-47003376New opportunities for biomarkers in cardiovascular risk stratification. Resolution of Advisory boardО. M. Drapkina0A. V. on behalf of the working group Kontsevaya1ФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииEarly detection of people with a high-risk of developing cardiovascular diseases is a key point of the prevention strategy. The existing risk scales have a number of limitations: insufficient accuracy for an individual or the appearance of a “residual risk”. Existing approaches to improving the accuracy of risk prediction include the use of biomarkers. Troponin I is promising, which has proven its prognostic value in healthy and asymptomatic individuals at the population level. For example, the BiomarCARE study with the participation of 74 thousand people from 5 countries showed an association of increased troponin I concentration and the frequency of cardiovascular events and overall mortality. Similar results were obtained in other cohorts. The simulation results indicate the potential economic feasibility of using troponin I for the purpose of risk stratification. The first pilot Russian study was conducted, which made it possible to describe the population distribution of troponin levels. It confirmed the prognostic significance of the biomarker in relation to the development of cardiovascular outcomes in men in the Russian population. Further studies on large cohorts are needed to clarify the results of the pilot project.https://russjcardiol.elpub.ru/jour/article/view/4700cardiovascular diseasesbiomarkerstroponin icardiovascular riskrisk stratification |
| spellingShingle | О. M. Drapkina A. V. on behalf of the working group Kontsevaya New opportunities for biomarkers in cardiovascular risk stratification. Resolution of Advisory board Российский кардиологический журнал cardiovascular diseases biomarkers troponin i cardiovascular risk risk stratification |
| title | New opportunities for biomarkers in cardiovascular risk stratification. Resolution of Advisory board |
| title_full | New opportunities for biomarkers in cardiovascular risk stratification. Resolution of Advisory board |
| title_fullStr | New opportunities for biomarkers in cardiovascular risk stratification. Resolution of Advisory board |
| title_full_unstemmed | New opportunities for biomarkers in cardiovascular risk stratification. Resolution of Advisory board |
| title_short | New opportunities for biomarkers in cardiovascular risk stratification. Resolution of Advisory board |
| title_sort | new opportunities for biomarkers in cardiovascular risk stratification resolution of advisory board |
| topic | cardiovascular diseases biomarkers troponin i cardiovascular risk risk stratification |
| url | https://russjcardiol.elpub.ru/jour/article/view/4700 |
| work_keys_str_mv | AT omdrapkina newopportunitiesforbiomarkersincardiovascularriskstratificationresolutionofadvisoryboard AT avonbehalfoftheworkinggroupkontsevaya newopportunitiesforbiomarkersincardiovascularriskstratificationresolutionofadvisoryboard |