Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance
Abstract Objective Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalances and insulin resistance (IR). Among the metabolic abnormalities associated with PCOS, obesity is often present concurrently. Nevertheless, the correlation between obesity, sex ho...
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BMC
2024-11-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-024-01789-w |
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| author | Haolin Zhang Weiyu Qiu Ping Zhou Li Shi Ziting Chen Yang Yang Yonghao Lu Lifei Zhou Hua Zhang Ming Cheng Yang Ye Rong Li |
| author_facet | Haolin Zhang Weiyu Qiu Ping Zhou Li Shi Ziting Chen Yang Yang Yonghao Lu Lifei Zhou Hua Zhang Ming Cheng Yang Ye Rong Li |
| author_sort | Haolin Zhang |
| collection | DOAJ |
| description | Abstract Objective Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalances and insulin resistance (IR). Among the metabolic abnormalities associated with PCOS, obesity is often present concurrently. Nevertheless, the correlation between obesity, sex hormone levels, and blood lipid profiles in PCOS patients with IR remains uncertain. Methods This is a cross-sectional study including a total of 206 Chinese women diagnosed with PCOS, enrolled between March 2016 and December 2021. The participants’ anthropometric measurements, such as weight, height, waist circumference, and hip circumference, were recorded. Additionally, fasting blood samples were collected to measure various parameters, including fasting glucose, insulin levels, lipid profiles, and sex hormone levels. Results Our findings highlight that obesity exhibited a significant correlation with lower levels of sex hormone binding globulin (SHBG) and elevated levels of free androgen index (FAI), fasting insulin, and HOMA-IR in PCOS patients diagnosed with IR. However, no significant association between obesity and blood lipid profiles was observed within this particular group of women. Conclusion This study suggests that among PCOS patients with IR, lower levels of SHBG and higher levels of FAI are associated with obesity. These findings indicate that SHBG and FAI may have the potential to serve as a biomarker for the initial identification and prognosis of IR in PCOS patients. Trial registration Retrospectively registered on 25/04/2020 at ClinicalTrials.gov Identifer: NCT04264832. |
| format | Article |
| id | doaj-art-4dcbcb1a4aa746ee8b31259010985576 |
| institution | DOAJ |
| issn | 1472-6823 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-4dcbcb1a4aa746ee8b312590109855762025-08-20T02:49:16ZengBMCBMC Endocrine Disorders1472-68232024-11-0124111110.1186/s12902-024-01789-wObesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistanceHaolin Zhang0Weiyu Qiu1Ping Zhou2Li Shi3Ziting Chen4Yang Yang5Yonghao Lu6Lifei Zhou7Hua Zhang8Ming Cheng9Yang Ye10Rong Li11Department of Traditional Chinese Medicine, Peking University Third HospitalThe Second Affiliated Hospital, Guangzhou Medical UniversityCenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third HospitalDepartment of Traditional Chinese Medicine, Peking University Third HospitalDepartment of Traditional Chinese Medicine, Peking University Third HospitalDepartment of Traditional Chinese Medicine, Peking University Third HospitalDepartment of Traditional Chinese Medicine, Peking University Third HospitalResearch Centre of Clinical Epidemiology, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third HospitalDepartment of Traditional Chinese Medicine, Peking University Third HospitalCenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third HospitalAbstract Objective Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalances and insulin resistance (IR). Among the metabolic abnormalities associated with PCOS, obesity is often present concurrently. Nevertheless, the correlation between obesity, sex hormone levels, and blood lipid profiles in PCOS patients with IR remains uncertain. Methods This is a cross-sectional study including a total of 206 Chinese women diagnosed with PCOS, enrolled between March 2016 and December 2021. The participants’ anthropometric measurements, such as weight, height, waist circumference, and hip circumference, were recorded. Additionally, fasting blood samples were collected to measure various parameters, including fasting glucose, insulin levels, lipid profiles, and sex hormone levels. Results Our findings highlight that obesity exhibited a significant correlation with lower levels of sex hormone binding globulin (SHBG) and elevated levels of free androgen index (FAI), fasting insulin, and HOMA-IR in PCOS patients diagnosed with IR. However, no significant association between obesity and blood lipid profiles was observed within this particular group of women. Conclusion This study suggests that among PCOS patients with IR, lower levels of SHBG and higher levels of FAI are associated with obesity. These findings indicate that SHBG and FAI may have the potential to serve as a biomarker for the initial identification and prognosis of IR in PCOS patients. Trial registration Retrospectively registered on 25/04/2020 at ClinicalTrials.gov Identifer: NCT04264832.https://doi.org/10.1186/s12902-024-01789-wPolycystic ovary syndromeInsulin resistanceObesitySex hormone binding globulinBlood lipid profiles |
| spellingShingle | Haolin Zhang Weiyu Qiu Ping Zhou Li Shi Ziting Chen Yang Yang Yonghao Lu Lifei Zhou Hua Zhang Ming Cheng Yang Ye Rong Li Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance BMC Endocrine Disorders Polycystic ovary syndrome Insulin resistance Obesity Sex hormone binding globulin Blood lipid profiles |
| title | Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance |
| title_full | Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance |
| title_fullStr | Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance |
| title_full_unstemmed | Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance |
| title_short | Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance |
| title_sort | obesity is associated with shbg levels rather than blood lipid profiles in pcos patients with insulin resistance |
| topic | Polycystic ovary syndrome Insulin resistance Obesity Sex hormone binding globulin Blood lipid profiles |
| url | https://doi.org/10.1186/s12902-024-01789-w |
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