Non-contrast enhanced functional lung MRI in children: report on 900 own measurements using matrix-pencil decomposition (MP-) MRI
ObjectivesFunctional imaging of the lungs enables a spatially resolved examination of pulmonary ventilation and perfusion. Non-contrast-enhanced (NCE) magnetic resonance imaging (MRI) techniques do not require specialized set-ups (e.g., hyperpolarized gases), but are applicable on standard clinical...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1519148/full |
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| author | Carmen Streibel Carmen Streibel Carmen Streibel Grzegorz Bauman Grzegorz Bauman Oliver Bieri Oliver Bieri Orso Pusterla Orso Pusterla Orso Pusterla Enno Stranzinger C. Corin Willers Marion Curdy Carmen Casaulta Bettina Sarah Frauchiger Insa Korten Sophie Yammine Yasmin Salem Philipp Latzin Elisabeth Kieninger |
| author_facet | Carmen Streibel Carmen Streibel Carmen Streibel Grzegorz Bauman Grzegorz Bauman Oliver Bieri Oliver Bieri Orso Pusterla Orso Pusterla Orso Pusterla Enno Stranzinger C. Corin Willers Marion Curdy Carmen Casaulta Bettina Sarah Frauchiger Insa Korten Sophie Yammine Yasmin Salem Philipp Latzin Elisabeth Kieninger |
| author_sort | Carmen Streibel |
| collection | DOAJ |
| description | ObjectivesFunctional imaging of the lungs enables a spatially resolved examination of pulmonary ventilation and perfusion. Non-contrast-enhanced (NCE) magnetic resonance imaging (MRI) techniques do not require specialized set-ups (e.g., hyperpolarized gases), but are applicable on standard clinical MRI scanners. Since patients are not exposed to ionizing radiation during the examinations, NCE-MRI is highly attractive for use in pediatrics, especially in children with chronic lung diseases requiring repeated follow-up measurements.Study designWe report on our own experience of more than 900 NCE-MRI measurements in children over seven years using matrix pencil decomposition (MP-)MRI. We present original data, i.e., clinical cases in which MP-MRI helped in clinical decision-making together with valuable practical points.ResultsAt our center, an optimized workflow including a child-friendly setting and automated provision of outcome protocols led to great acceptance of functional NCE-MRI in patients and clinicians. Within this setting, regular MP-MRI measurements were successfully implemented into clinical routine and proved to be very helpful for surveillance and specific clinical decision-making. We present exemplary cases illustrating the potential of NCE-MRI as a diagnostic tool.ConclusionIn this article, we summarize our unique experience of a large number of MP-MRI measurements. We give an overview on our workflow including standardized and automated analysis and reporting. The exemplary cases from different disease groups illustrate its value in the clinical setting. In conclusion, visualizing regional functional deficits and respective underlying pathophysiological nature of lung impairment seems promising for increasing use of NCE-MRI in the future. |
| format | Article |
| id | doaj-art-4dbc889a3a8f43e28647812c4370c851 |
| institution | DOAJ |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-4dbc889a3a8f43e28647812c4370c8512025-08-20T02:59:20ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-03-011310.3389/fped.2025.15191481519148Non-contrast enhanced functional lung MRI in children: report on 900 own measurements using matrix-pencil decomposition (MP-) MRICarmen Streibel0Carmen Streibel1Carmen Streibel2Grzegorz Bauman3Grzegorz Bauman4Oliver Bieri5Oliver Bieri6Orso Pusterla7Orso Pusterla8Orso Pusterla9Enno Stranzinger10C. Corin Willers11Marion Curdy12Carmen Casaulta13Bettina Sarah Frauchiger14Insa Korten15Sophie Yammine16Yasmin Salem17Philipp Latzin18Elisabeth Kieninger19Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandGraduate Schoolfor Health Sciences, University of Bern, Bern, SwitzerlandDepartment of General Internal Medicine and Psychosomatic, Heidelberg University Hospital, University of Heidelberg, Heidelberg, GermanyDepartment of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, SwitzerlandDepartment of Biomedical Engineering, University of Basel, Allschwil, SwitzerlandDepartment of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, SwitzerlandDepartment of Biomedical Engineering, University of Basel, Allschwil, SwitzerlandDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, SwitzerlandDepartment of Biomedical Engineering, University of Basel, Allschwil, SwitzerlandDepartment of Diagnostic and Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, Bern, SwitzerlandDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandObjectivesFunctional imaging of the lungs enables a spatially resolved examination of pulmonary ventilation and perfusion. Non-contrast-enhanced (NCE) magnetic resonance imaging (MRI) techniques do not require specialized set-ups (e.g., hyperpolarized gases), but are applicable on standard clinical MRI scanners. Since patients are not exposed to ionizing radiation during the examinations, NCE-MRI is highly attractive for use in pediatrics, especially in children with chronic lung diseases requiring repeated follow-up measurements.Study designWe report on our own experience of more than 900 NCE-MRI measurements in children over seven years using matrix pencil decomposition (MP-)MRI. We present original data, i.e., clinical cases in which MP-MRI helped in clinical decision-making together with valuable practical points.ResultsAt our center, an optimized workflow including a child-friendly setting and automated provision of outcome protocols led to great acceptance of functional NCE-MRI in patients and clinicians. Within this setting, regular MP-MRI measurements were successfully implemented into clinical routine and proved to be very helpful for surveillance and specific clinical decision-making. We present exemplary cases illustrating the potential of NCE-MRI as a diagnostic tool.ConclusionIn this article, we summarize our unique experience of a large number of MP-MRI measurements. We give an overview on our workflow including standardized and automated analysis and reporting. The exemplary cases from different disease groups illustrate its value in the clinical setting. In conclusion, visualizing regional functional deficits and respective underlying pathophysiological nature of lung impairment seems promising for increasing use of NCE-MRI in the future.https://www.frontiersin.org/articles/10.3389/fped.2025.1519148/fullfunctional lung MRIchildrenlung functionMP-MRIpulmonology |
| spellingShingle | Carmen Streibel Carmen Streibel Carmen Streibel Grzegorz Bauman Grzegorz Bauman Oliver Bieri Oliver Bieri Orso Pusterla Orso Pusterla Orso Pusterla Enno Stranzinger C. Corin Willers Marion Curdy Carmen Casaulta Bettina Sarah Frauchiger Insa Korten Sophie Yammine Yasmin Salem Philipp Latzin Elisabeth Kieninger Non-contrast enhanced functional lung MRI in children: report on 900 own measurements using matrix-pencil decomposition (MP-) MRI Frontiers in Pediatrics functional lung MRI children lung function MP-MRI pulmonology |
| title | Non-contrast enhanced functional lung MRI in children: report on 900 own measurements using matrix-pencil decomposition (MP-) MRI |
| title_full | Non-contrast enhanced functional lung MRI in children: report on 900 own measurements using matrix-pencil decomposition (MP-) MRI |
| title_fullStr | Non-contrast enhanced functional lung MRI in children: report on 900 own measurements using matrix-pencil decomposition (MP-) MRI |
| title_full_unstemmed | Non-contrast enhanced functional lung MRI in children: report on 900 own measurements using matrix-pencil decomposition (MP-) MRI |
| title_short | Non-contrast enhanced functional lung MRI in children: report on 900 own measurements using matrix-pencil decomposition (MP-) MRI |
| title_sort | non contrast enhanced functional lung mri in children report on 900 own measurements using matrix pencil decomposition mp mri |
| topic | functional lung MRI children lung function MP-MRI pulmonology |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1519148/full |
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