Changes in immune cell signatures during early infection reflect decoupling of capillary perfusion and glycocalyx dimensions

Changes in immune cell signatures during early infection reflect decoupling of capillary perfusion and glycocalyx dimensions

IntroductionMicrovascular injury is central to the pathophysiology of sepsis, but its interaction with the immune system in early infection is unclear. This study aimed to phenotype peripheral blood mononuclear cells (PBMC) from emergency department (ED) patients with suspected bacterial infection a...

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Bibliographic Details
Main Authors: Anna Hunkemöller, Timo Wirth, Alexandros Rovas, Hermann Pavenstädt, Luisa Klotz, Philipp Kümpers
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
sepsis
microcirculation
sublingual microscopy
endothelial glycocalyx
immune phenotypes
flow cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589959/full
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