Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
Abstract AS01-adjuvanted shingles (herpes zoster) vaccination is associated with a lower risk of dementia, but the underlying mechanisms are unclear. In propensity-score matched cohort studies with 436,788 individuals, both the AS01-adjuvanted shingles and respiratory syncytial virus (RSV) vaccines,...
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| Format: | Article |
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Nature Portfolio
2025-06-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-025-01172-3 |
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| author | Maxime Taquet John A. Todd Paul J. Harrison |
| author_facet | Maxime Taquet John A. Todd Paul J. Harrison |
| author_sort | Maxime Taquet |
| collection | DOAJ |
| description | Abstract AS01-adjuvanted shingles (herpes zoster) vaccination is associated with a lower risk of dementia, but the underlying mechanisms are unclear. In propensity-score matched cohort studies with 436,788 individuals, both the AS01-adjuvanted shingles and respiratory syncytial virus (RSV) vaccines, individually or combined, were associated with reduced 18-month risk of dementia. No difference was observed between the two AS01-adjuvanted vaccines, suggesting that the AS01 adjuvant itself plays a direct role in lowering dementia risk. |
| format | Article |
| id | doaj-art-4db7f4271d4d47b8a2104249e81ad1e8 |
| institution | OA Journals |
| issn | 2059-0105 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
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| series | npj Vaccines |
| spelling | doaj-art-4db7f4271d4d47b8a2104249e81ad1e82025-08-20T02:35:39ZengNature Portfolionpj Vaccines2059-01052025-06-011011610.1038/s41541-025-01172-3Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infectionsMaxime Taquet0John A. Todd1Paul J. Harrison2Department of Psychiatry, University of OxfordCentre for Human Genetics, Nuffield Department of Medicine, University of OxfordDepartment of Psychiatry, University of OxfordAbstract AS01-adjuvanted shingles (herpes zoster) vaccination is associated with a lower risk of dementia, but the underlying mechanisms are unclear. In propensity-score matched cohort studies with 436,788 individuals, both the AS01-adjuvanted shingles and respiratory syncytial virus (RSV) vaccines, individually or combined, were associated with reduced 18-month risk of dementia. No difference was observed between the two AS01-adjuvanted vaccines, suggesting that the AS01 adjuvant itself plays a direct role in lowering dementia risk.https://doi.org/10.1038/s41541-025-01172-3 |
| spellingShingle | Maxime Taquet John A. Todd Paul J. Harrison Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections npj Vaccines |
| title | Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections |
| title_full | Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections |
| title_fullStr | Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections |
| title_full_unstemmed | Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections |
| title_short | Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections |
| title_sort | lower risk of dementia with as01 adjuvanted vaccination against shingles and respiratory syncytial virus infections |
| url | https://doi.org/10.1038/s41541-025-01172-3 |
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