Physalin B Suppresses Inflammatory Response to Lipopolysaccharide in RAW264.7 Cells by Inhibiting NF-κB Signaling
Physalin B from Physalis angulata L. (Solanaceae) is a naturally occurring secosteroid with multiple biological activities. But its anti-inflammatory activity and mechanism remain unclear. Physalin B effects on RAW264.7 macrophages stimulated by lipopolysaccharide (LPS) were observed in this study....
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2018/7943140 |
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| author | Yanjun Yang Lang Yi Qing Wang Bingbing Xie Congwei Sha Yan Dong |
| author_facet | Yanjun Yang Lang Yi Qing Wang Bingbing Xie Congwei Sha Yan Dong |
| author_sort | Yanjun Yang |
| collection | DOAJ |
| description | Physalin B from Physalis angulata L. (Solanaceae) is a naturally occurring secosteroid with multiple biological activities. But its anti-inflammatory activity and mechanism remain unclear. Physalin B effects on RAW264.7 macrophages stimulated by lipopolysaccharide (LPS) were observed in this study. The expression and secretion of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) induced by LPS were significantly inhibited by physalin B. Meanwhile, the NF-κB nuclear translocation induced by LPS was inhibited by physalin B. The anti-inflammatory effects of physalin B could not be inhibited by mifepristone (RU486), the blocker of glucocorticoid receptor. In conclusion, physalin B can suppress inflammatory response to LPS in macrophages by inhibiting the production of inflammatory cytokines via NF-κB signaling. |
| format | Article |
| id | doaj-art-4db615fbf2714976b2ace5c90ff6282b |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-4db615fbf2714976b2ace5c90ff6282b2025-02-03T05:45:14ZengWileyJournal of Chemistry2090-90632090-90712018-01-01201810.1155/2018/79431407943140Physalin B Suppresses Inflammatory Response to Lipopolysaccharide in RAW264.7 Cells by Inhibiting NF-κB SignalingYanjun Yang0Lang Yi1Qing Wang2Bingbing Xie3Congwei Sha4Yan Dong5Department of Pharmacy, Guangdong Food and Drug Vocational College, Tianhe District, Guangzhou 510520, ChinaDepartment of Immunology, Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Baiyun District, Guangzhou 510405, ChinaDepartment of Immunology, Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Baiyun District, Guangzhou 510405, ChinaDepartment of Immunology, Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Baiyun District, Guangzhou 510405, ChinaGuangdong Provincial Institute of Biological Products and Materia Medica, Baiyun District, Guangzhou 510440, ChinaDepartment of Immunology, Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Baiyun District, Guangzhou 510405, ChinaPhysalin B from Physalis angulata L. (Solanaceae) is a naturally occurring secosteroid with multiple biological activities. But its anti-inflammatory activity and mechanism remain unclear. Physalin B effects on RAW264.7 macrophages stimulated by lipopolysaccharide (LPS) were observed in this study. The expression and secretion of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) induced by LPS were significantly inhibited by physalin B. Meanwhile, the NF-κB nuclear translocation induced by LPS was inhibited by physalin B. The anti-inflammatory effects of physalin B could not be inhibited by mifepristone (RU486), the blocker of glucocorticoid receptor. In conclusion, physalin B can suppress inflammatory response to LPS in macrophages by inhibiting the production of inflammatory cytokines via NF-κB signaling.http://dx.doi.org/10.1155/2018/7943140 |
| spellingShingle | Yanjun Yang Lang Yi Qing Wang Bingbing Xie Congwei Sha Yan Dong Physalin B Suppresses Inflammatory Response to Lipopolysaccharide in RAW264.7 Cells by Inhibiting NF-κB Signaling Journal of Chemistry |
| title | Physalin B Suppresses Inflammatory Response to Lipopolysaccharide in RAW264.7 Cells by Inhibiting NF-κB Signaling |
| title_full | Physalin B Suppresses Inflammatory Response to Lipopolysaccharide in RAW264.7 Cells by Inhibiting NF-κB Signaling |
| title_fullStr | Physalin B Suppresses Inflammatory Response to Lipopolysaccharide in RAW264.7 Cells by Inhibiting NF-κB Signaling |
| title_full_unstemmed | Physalin B Suppresses Inflammatory Response to Lipopolysaccharide in RAW264.7 Cells by Inhibiting NF-κB Signaling |
| title_short | Physalin B Suppresses Inflammatory Response to Lipopolysaccharide in RAW264.7 Cells by Inhibiting NF-κB Signaling |
| title_sort | physalin b suppresses inflammatory response to lipopolysaccharide in raw264 7 cells by inhibiting nf κb signaling |
| url | http://dx.doi.org/10.1155/2018/7943140 |
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