Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems

Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems

Abstract Despite the advance and success of precision oncology in gastrointestinal cancers, the frequency of molecular‐informed therapy decisions in pancreatic ductal adenocarcinoma (PDAC) is currently neglectable. We present a longitudinal precision oncology platform based on functional model syste...

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Main Authors: Katja Peschke, Hannah Jakubowsky, Arlett Schäfer, Carlo Maurer, Sebastian Lange, Felix Orben, Raquel Bernad, Felix N Harder, Matthias Eiber, Rupert Öllinger, Katja Steiger, Melissa Schlitter, Wilko Weichert, Ulrich Mayr, Veit Phillip, Christoph Schlag, Roland M Schmid, Rickmer F Braren, Bo Kong, Ihsan Ekin Demir, Helmut Friess, Roland Rad, Dieter Saur, Günter Schneider, Maximilian Reichert
Format: Article
Language:English
Published: Springer Nature 2022-02-01
Series:EMBO Molecular Medicine
Subjects:
functional screening
pancreatic cancer
precision oncology
therapy‐induced vulnerabilities
tumor cell plasticity
Online Access:https://doi.org/10.15252/emmm.202114876
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