Current status and challenges of multi-omics research using animal models of atherosclerosis
Atherosclerosis is an underlying cause of cardiovascular diseases (CVD) which account for most deaths worldwide. Use of diverse preclinical models of atherosclerosis has been implemental in understanding the underlying mechanisms, the implicated cell types, the genes and the molecules at play in the...
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Elsevier
2025-09-01
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| Series: | Journal of Molecular and Cellular Cardiology Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772976125001953 |
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| author | Tijana Mitić Adriana Georgescu Nicoleta Alexandru-Moise Michael J. Davies Cecile Vindis Susana Novella Eva Gerdts Georgios Kararigas Stephanie Bezzina Wettinger Melissa M. Formosa Brenda R. Kwak Filippo Molica Nuria Amigo Andrea Caporali Fernando de la Cuesta Ignacio Fernando Hall Angeliki Chroni Fabio Martelli Johannes A. Schmid Paolo Magni Dimitris Kardassis |
| author_facet | Tijana Mitić Adriana Georgescu Nicoleta Alexandru-Moise Michael J. Davies Cecile Vindis Susana Novella Eva Gerdts Georgios Kararigas Stephanie Bezzina Wettinger Melissa M. Formosa Brenda R. Kwak Filippo Molica Nuria Amigo Andrea Caporali Fernando de la Cuesta Ignacio Fernando Hall Angeliki Chroni Fabio Martelli Johannes A. Schmid Paolo Magni Dimitris Kardassis |
| author_sort | Tijana Mitić |
| collection | DOAJ |
| description | Atherosclerosis is an underlying cause of cardiovascular diseases (CVD) which account for most deaths worldwide. Use of diverse preclinical models of atherosclerosis has been implemental in understanding the underlying mechanisms, the implicated cell types, the genes and the molecules at play in the onset and progression of atherosclerotic plaques. Although significant research advancements have been made, further research is necessary to delve into factors influencing plaque types, site preference within the vasculature, interactions with adjacent tissues (liver, pancreas and perivascular adipose tissue), inflammation and sex-based disparities, among others. The conventional low throughput methodologies which concentrate on individual cells, genes or metabolites are inadequate to tackle the complex and heterogeneous nature of atherosclerosis. With recent advancement in multi-omics and bioinformatics, research approaches have illuminated a clearer understanding of atherosclerosis. Consequently, these advancements pave the path to design novel therapeutics to complement currently approved lipid-lowering and other effective treatments. In this article, we summarize and critically evaluate the findings derived from recent high throughput single- or multi-omic studies conducted in animal models of atherosclerosis. We also delve into the challenges associated with using experimental animals to model human atherosclerosis and contemplate the essential enhancements needed to better mimic human conditions. We further discuss the requirement of establishing a structured multi-omic database for atherosclerosis research, enabling broader access and utilisation within the scientific community. |
| format | Article |
| id | doaj-art-4db3961e69ba4e1194d7e30819bdbced |
| institution | Kabale University |
| issn | 2772-9761 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Molecular and Cellular Cardiology Plus |
| spelling | doaj-art-4db3961e69ba4e1194d7e30819bdbced2025-08-20T03:51:25ZengElsevierJournal of Molecular and Cellular Cardiology Plus2772-97612025-09-011310047610.1016/j.jmccpl.2025.100476Current status and challenges of multi-omics research using animal models of atherosclerosisTijana Mitić0Adriana Georgescu1Nicoleta Alexandru-Moise2Michael J. Davies3Cecile Vindis4Susana Novella5Eva Gerdts6Georgios Kararigas7Stephanie Bezzina Wettinger8Melissa M. Formosa9Brenda R. Kwak10Filippo Molica11Nuria Amigo12Andrea Caporali13Fernando de la Cuesta14Ignacio Fernando Hall15Angeliki Chroni16Fabio Martelli17Johannes A. Schmid18Paolo Magni19Dimitris Kardassis20Centre for Cardiovascular Science (CVS), Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh BioQuarter, United Kingdom; Correspondence to: T. Mitić, Centre for Cardiovascular Science (CVS), Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.Department of Pathophysiology and Cellular Pharmacology, Institute of Cellular Biology and Pathology 'Nicolae Simionescu', Bucharest, RomaniaDepartment of Pathophysiology and Cellular Pharmacology, Institute of Cellular Biology and Pathology 'Nicolae Simionescu', Bucharest, RomaniaDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, DenmarkCARDIOMET, Center for Clinical Investigation 1436 (CIC1436)/INSERM, Toulouse, FranceDepartment of Physiology, University of Valencia - INCLIVA Biomedical Research Institute, Valencia, SpainDepartment of Clinical Science, University of Bergen, Bergen, NorwayDepartment of Physiology, Faculty of Medicine, University of Iceland, Reykjavik, IcelandDepartment of Applied Biomedical Science, Faculty of Health Sciences and Centre for Molecular Medicine and Biobanking, University of Malta, MaltaDepartment of Applied Biomedical Science, Faculty of Health Sciences and Centre for Molecular Medicine and Biobanking, University of Malta, MaltaDepartment of Pathology and Immunology and Geneva Centre for Inflammation Research, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDepartment of Pathology and Immunology and Geneva Centre for Inflammation Research, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDepartment of Basic Medical Sciences, Universitat Rovira i Virgili, Reus, Spain; Center for Biomedical Research in Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Biosfer Teslab, Reus, SpainCentre for Cardiovascular Science (CVS), Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh BioQuarter, United KingdomDepartment of Pharmacology and Therapeutics, School of Medicine, Universidad Autónoma de Madrid, Spain; Instituto de Investigación Sanitaria del Hospital, Universitario La Paz (IdiPAZ), Madrid, SpainCentre for Cardiovascular Science (CVS), Queen's Medical Research Institute (QMRI), University of Edinburgh, Edinburgh BioQuarter, United KingdomInstitute of Biosciences and Applications, National Center for Scientific Research “Demokritos”, Athens, GreeceMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, Milan, ItalyInstitute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, AustriaDepartment of Pharmacological and Biomolecular Sciences ‘Rodolfo Paoletti’, Università degli Studi di Milano, Milan, Italy; IRCCS MultiMedica, Milan, ItalyIRCCS MultiMedica, Milan, Italy; Department of Basic Sciences, University of Crete Medical School, Heraklion, Greece; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology of Hellas, Heraklion, Greece; Correspondence to: D. Kardassis, University of Crete Medical School and Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology of Hellas, Heraklion 71003, Greece.Atherosclerosis is an underlying cause of cardiovascular diseases (CVD) which account for most deaths worldwide. Use of diverse preclinical models of atherosclerosis has been implemental in understanding the underlying mechanisms, the implicated cell types, the genes and the molecules at play in the onset and progression of atherosclerotic plaques. Although significant research advancements have been made, further research is necessary to delve into factors influencing plaque types, site preference within the vasculature, interactions with adjacent tissues (liver, pancreas and perivascular adipose tissue), inflammation and sex-based disparities, among others. The conventional low throughput methodologies which concentrate on individual cells, genes or metabolites are inadequate to tackle the complex and heterogeneous nature of atherosclerosis. With recent advancement in multi-omics and bioinformatics, research approaches have illuminated a clearer understanding of atherosclerosis. Consequently, these advancements pave the path to design novel therapeutics to complement currently approved lipid-lowering and other effective treatments. In this article, we summarize and critically evaluate the findings derived from recent high throughput single- or multi-omic studies conducted in animal models of atherosclerosis. We also delve into the challenges associated with using experimental animals to model human atherosclerosis and contemplate the essential enhancements needed to better mimic human conditions. We further discuss the requirement of establishing a structured multi-omic database for atherosclerosis research, enabling broader access and utilisation within the scientific community.http://www.sciencedirect.com/science/article/pii/S2772976125001953Cardiovascular diseasesAtherosclerosisAnimal modelsTranscriptomicsProteomicsLipidomics |
| spellingShingle | Tijana Mitić Adriana Georgescu Nicoleta Alexandru-Moise Michael J. Davies Cecile Vindis Susana Novella Eva Gerdts Georgios Kararigas Stephanie Bezzina Wettinger Melissa M. Formosa Brenda R. Kwak Filippo Molica Nuria Amigo Andrea Caporali Fernando de la Cuesta Ignacio Fernando Hall Angeliki Chroni Fabio Martelli Johannes A. Schmid Paolo Magni Dimitris Kardassis Current status and challenges of multi-omics research using animal models of atherosclerosis Journal of Molecular and Cellular Cardiology Plus Cardiovascular diseases Atherosclerosis Animal models Transcriptomics Proteomics Lipidomics |
| title | Current status and challenges of multi-omics research using animal models of atherosclerosis |
| title_full | Current status and challenges of multi-omics research using animal models of atherosclerosis |
| title_fullStr | Current status and challenges of multi-omics research using animal models of atherosclerosis |
| title_full_unstemmed | Current status and challenges of multi-omics research using animal models of atherosclerosis |
| title_short | Current status and challenges of multi-omics research using animal models of atherosclerosis |
| title_sort | current status and challenges of multi omics research using animal models of atherosclerosis |
| topic | Cardiovascular diseases Atherosclerosis Animal models Transcriptomics Proteomics Lipidomics |
| url | http://www.sciencedirect.com/science/article/pii/S2772976125001953 |
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