Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics

Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics

Abstract Cellular senescence is a double-edged sword in cancer biology, functioning as both a tumor-suppressive mechanism and a driver of malignancy. Initially, senescence acts as a protective barrier by arresting the proliferation of damaged or oncogene-expressing cells via pathways such as oncogen...

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Bibliographic Details
Main Authors: Tiejun Feng, Fuda Xie, Leo M.Y. Lee, Zhiqiang Lin, Yifan Tu, Yang Lyu, Peiyao Yu, Jialin Wu, Bonan Chen, Ge Zhang, Gary M.K. Tse, Ka Fai To, Wei Kang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Molecular Cancer
Subjects:
Senescence
Cancer
Therapeutic innovation
Online Access:https://doi.org/10.1186/s12943-025-02419-2
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