Cathodic Stripping Voltammetric Determination of Dimenhydrinate
Dimenhydrinate (DMH) is a derivative of theophylline (diphenhydramine salt of 8-chloro theophylline). Both dimenhydrinate and theophylline are used as antihistamines in treatment of asthma, in addition to other important pharmaceutical uses. A three-electrode voltammetric system was used, with hangi...
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An-Najah National University
2014-09-01
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| Series: | مجلة جامعة النجاح للأبحاث العلوم الطبيعية |
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| Online Access: | https://journals.najah.edu/media/journals/full_texts/3_f6as6hm.pdf |
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| author | Raqi Shubietah Ali Abu Zuhri |
| author_facet | Raqi Shubietah Ali Abu Zuhri |
| author_sort | Raqi Shubietah |
| collection | DOAJ |
| description | Dimenhydrinate (DMH) is a derivative of theophylline (diphenhydramine salt of 8-chloro theophylline). Both dimenhydrinate and theophylline are used as antihistamines in treatment of asthma, in addition to other important pharmaceutical uses. A three-electrode voltammetric system was used, with hanging mercury drop electrode (HMDE) as working electrode. A reduction peak of DMH at -0.2 to -0.3 V in acetate buffer, pH about 4.0 is obtained. The peak height is increased largely (tripled) in presence of Cu2+, due to the formation of DMH-Cu (I) complex. The detection limit is as low as 5x10-9 M DMH. Application of the analysis of two drugs containing dimenhydrinate was carried out, where a coefficient of variation of about 3% was obtained. |
| format | Article |
| id | doaj-art-4db1eba2d60a49b3ae004e26482af552 |
| institution | Kabale University |
| issn | 1727-2114 2311-8865 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | An-Najah National University |
| record_format | Article |
| series | مجلة جامعة النجاح للأبحاث العلوم الطبيعية |
| spelling | doaj-art-4db1eba2d60a49b3ae004e26482af5522025-08-20T04:00:44ZengAn-Najah National Universityمجلة جامعة النجاح للأبحاث العلوم الطبيعية1727-21142311-88652014-09-01291455810.35552/anujr.a.29.1.1157Cathodic Stripping Voltammetric Determination of DimenhydrinateRaqi Shubietah0Ali Abu Zuhri1Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, PalestineNoneDimenhydrinate (DMH) is a derivative of theophylline (diphenhydramine salt of 8-chloro theophylline). Both dimenhydrinate and theophylline are used as antihistamines in treatment of asthma, in addition to other important pharmaceutical uses. A three-electrode voltammetric system was used, with hanging mercury drop electrode (HMDE) as working electrode. A reduction peak of DMH at -0.2 to -0.3 V in acetate buffer, pH about 4.0 is obtained. The peak height is increased largely (tripled) in presence of Cu2+, due to the formation of DMH-Cu (I) complex. The detection limit is as low as 5x10-9 M DMH. Application of the analysis of two drugs containing dimenhydrinate was carried out, where a coefficient of variation of about 3% was obtained.https://journals.najah.edu/media/journals/full_texts/3_f6as6hm.pdfdimenhydrinatevoltammetric analysisstripping voltammetric determination |
| spellingShingle | Raqi Shubietah Ali Abu Zuhri Cathodic Stripping Voltammetric Determination of Dimenhydrinate مجلة جامعة النجاح للأبحاث العلوم الطبيعية dimenhydrinate voltammetric analysis stripping voltammetric determination |
| title | Cathodic Stripping Voltammetric Determination of Dimenhydrinate |
| title_full | Cathodic Stripping Voltammetric Determination of Dimenhydrinate |
| title_fullStr | Cathodic Stripping Voltammetric Determination of Dimenhydrinate |
| title_full_unstemmed | Cathodic Stripping Voltammetric Determination of Dimenhydrinate |
| title_short | Cathodic Stripping Voltammetric Determination of Dimenhydrinate |
| title_sort | cathodic stripping voltammetric determination of dimenhydrinate |
| topic | dimenhydrinate voltammetric analysis stripping voltammetric determination |
| url | https://journals.najah.edu/media/journals/full_texts/3_f6as6hm.pdf |
| work_keys_str_mv | AT raqishubietah cathodicstrippingvoltammetricdeterminationofdimenhydrinate AT aliabuzuhri cathodicstrippingvoltammetricdeterminationofdimenhydrinate |