A Novel Rat Model of Orthodontic Tooth Movement Using Temporary Skeletal Anchorage Devices: 3D Finite Element Analysis and In Vivo Validation
The aim of this animal study was to develop a model of orthodontic tooth movement using a microimplant as a TSAD in rodents. A finite element model of the TSAD in alveolar bone was built using μCT images of rat maxilla to determine the von Mises stresses and displacement in the alveolar bone surroun...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2014/917535 |
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| author | Neelambar Kaipatur Yuchin Wu Samer Adeeb Thomas Stevenson Paul Major Michael Doschak |
| author_facet | Neelambar Kaipatur Yuchin Wu Samer Adeeb Thomas Stevenson Paul Major Michael Doschak |
| author_sort | Neelambar Kaipatur |
| collection | DOAJ |
| description | The aim of this animal study was to develop a model of orthodontic tooth movement using a microimplant as a TSAD in rodents. A finite element model of the TSAD in alveolar bone was built using μCT images of rat maxilla to determine the von Mises stresses and displacement in the alveolar bone surrounding the TSAD. For in vivo validation of the FE model, Sprague-Dawley rats (n=25) were used and a Stryker 1.2 × 3 mm microimplant was inserted in the right maxilla and used to protract the right first permanent molar using a NiTi closed coil spring. Tooth movement measurements were taken at baseline, 4 and 8 weeks. At 8 weeks, animals were euthanized and tissues were analyzed by histology and EPMA. FE modeling showed maximum von Mises stress of 45 Mpa near the apex of TSAD but the average von Mises stress was under 25 Mpa. Appreciable tooth movement of 0.62 ± 0.04 mm at 4 weeks and 1.99 ± 0.14 mm at 8 weeks was obtained. Histological and EPMA results demonstrated no active bone remodeling around the TSAD at 8 weeks depicting good secondary stability. This study provided evidence that protracted tooth movement is achieved in small animals using TSADs. |
| format | Article |
| id | doaj-art-4dab4882270a4e30b64a62907a343918 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-4dab4882270a4e30b64a62907a3439182025-02-03T06:12:22ZengWileyInternational Journal of Dentistry1687-87281687-87362014-01-01201410.1155/2014/917535917535A Novel Rat Model of Orthodontic Tooth Movement Using Temporary Skeletal Anchorage Devices: 3D Finite Element Analysis and In Vivo ValidationNeelambar Kaipatur0Yuchin Wu1Samer Adeeb2Thomas Stevenson3Paul Major4Michael Doschak5Division of Orthodontics, University of Alberta, Edmonton, AB, T6G 2E1, CanadaBiomedical Engineering, University of Alberta, Edmonton, AB, T6G 2E1, CanadaBiomedical Engineering, University of Alberta, Edmonton, AB, T6G 2E1, CanadaDepartment of Dentistry, University of Alberta, Edmonton, AB, T6G 2E1, CanadaDivision of Orthodontics, University of Alberta, Edmonton, AB, T6G 2E1, CanadaBiomedical Engineering, University of Alberta, Edmonton, AB, T6G 2E1, CanadaThe aim of this animal study was to develop a model of orthodontic tooth movement using a microimplant as a TSAD in rodents. A finite element model of the TSAD in alveolar bone was built using μCT images of rat maxilla to determine the von Mises stresses and displacement in the alveolar bone surrounding the TSAD. For in vivo validation of the FE model, Sprague-Dawley rats (n=25) were used and a Stryker 1.2 × 3 mm microimplant was inserted in the right maxilla and used to protract the right first permanent molar using a NiTi closed coil spring. Tooth movement measurements were taken at baseline, 4 and 8 weeks. At 8 weeks, animals were euthanized and tissues were analyzed by histology and EPMA. FE modeling showed maximum von Mises stress of 45 Mpa near the apex of TSAD but the average von Mises stress was under 25 Mpa. Appreciable tooth movement of 0.62 ± 0.04 mm at 4 weeks and 1.99 ± 0.14 mm at 8 weeks was obtained. Histological and EPMA results demonstrated no active bone remodeling around the TSAD at 8 weeks depicting good secondary stability. This study provided evidence that protracted tooth movement is achieved in small animals using TSADs.http://dx.doi.org/10.1155/2014/917535 |
| spellingShingle | Neelambar Kaipatur Yuchin Wu Samer Adeeb Thomas Stevenson Paul Major Michael Doschak A Novel Rat Model of Orthodontic Tooth Movement Using Temporary Skeletal Anchorage Devices: 3D Finite Element Analysis and In Vivo Validation International Journal of Dentistry |
| title | A Novel Rat Model of Orthodontic Tooth Movement Using Temporary Skeletal Anchorage Devices: 3D Finite Element Analysis and In Vivo Validation |
| title_full | A Novel Rat Model of Orthodontic Tooth Movement Using Temporary Skeletal Anchorage Devices: 3D Finite Element Analysis and In Vivo Validation |
| title_fullStr | A Novel Rat Model of Orthodontic Tooth Movement Using Temporary Skeletal Anchorage Devices: 3D Finite Element Analysis and In Vivo Validation |
| title_full_unstemmed | A Novel Rat Model of Orthodontic Tooth Movement Using Temporary Skeletal Anchorage Devices: 3D Finite Element Analysis and In Vivo Validation |
| title_short | A Novel Rat Model of Orthodontic Tooth Movement Using Temporary Skeletal Anchorage Devices: 3D Finite Element Analysis and In Vivo Validation |
| title_sort | novel rat model of orthodontic tooth movement using temporary skeletal anchorage devices 3d finite element analysis and in vivo validation |
| url | http://dx.doi.org/10.1155/2014/917535 |
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