Cognitive bias modification for social anxiety: protocol for a living systematic review of human studies and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]

Background Social anxiety is a heightened fear and discomfort in social situations. Cases of elevated distress and impaired functioning can lead to a clinical diagnosis of social anxiety disorder. Altering cognitive biases associated with social anxiety has been suggested as potentially beneficial;...

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Main Authors: Paulina Schenk, Virginia Chiocchia, Hossein Dehdarirad, Janna Hastings, Claire Stansfield, Toshi Furukawa, Simon E. Blackwell, Ava Homiar, Thomy Tonia, Per Carlbring, Kelvin Opiepie, Claire Friedrich, Simonne Wright, Susan Michie, Georgia Salanti, Richardson Mojica, James Thomas, Jaycee Kennett, Andrea Cipriani, Jennifer Potts
Format: Article
Language:English
Published: Wellcome 2025-05-01
Series:Wellcome Open Research
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Online Access:https://wellcomeopenresearch.org/articles/9-657/v2
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author Paulina Schenk
Virginia Chiocchia
Hossein Dehdarirad
Janna Hastings
Claire Stansfield
Toshi Furukawa
Simon E. Blackwell
Ava Homiar
Thomy Tonia
Per Carlbring
Kelvin Opiepie
Claire Friedrich
Simonne Wright
Susan Michie
Georgia Salanti
Richardson Mojica
James Thomas
Jaycee Kennett
Andrea Cipriani
Jennifer Potts
author_facet Paulina Schenk
Virginia Chiocchia
Hossein Dehdarirad
Janna Hastings
Claire Stansfield
Toshi Furukawa
Simon E. Blackwell
Ava Homiar
Thomy Tonia
Per Carlbring
Kelvin Opiepie
Claire Friedrich
Simonne Wright
Susan Michie
Georgia Salanti
Richardson Mojica
James Thomas
Jaycee Kennett
Andrea Cipriani
Jennifer Potts
author_sort Paulina Schenk
collection DOAJ
description Background Social anxiety is a heightened fear and discomfort in social situations. Cases of elevated distress and impaired functioning can lead to a clinical diagnosis of social anxiety disorder. Altering cognitive biases associated with social anxiety has been suggested as potentially beneficial; however, little is known about the comparative effectiveness of such interventions. The aim of this living systematic review is to examine the efficacy of cognitive bias modification for reducing social anxiety. Methods We will search multiple electronic databases for randomised controlled trials evaluating the efficacy of cognitive bias modification for people diagnosed with social anxiety and people exposed to a social stressor. The primary outcome will be change in social anxiety related symptoms; secondary outcomes will be changes in social functioning and quality of life and adverse events. Study selection, data extraction and risk of bias assessment will be done by at least two reviewers using pre-defined tools. We will synthesise data from people with social anxiety diagnosis and those subjected to a simulated social stressor separately using random effects meta-analyses. Heterogeneity will be evaluated by investigating characteristics of included studies and we will conduct a network meta-analysis in order to compare the efficacy of subtypes of cognitive bias modification for social anxiety disorder. We will appraise the strength of the evidence for each outcome by reviewing the overall association, internal and external validity, and reporting biases. Where data allows, we will triangulate the evidence from both sources with a multidisciplinary group of experts. We will also descriptively report factors reported to mediate cognitive bias modification, The review will begin in living mode and the database search will be rerun every three months to identify potential new evidence. We will co-produce this review with members of a global lived experience advisory board. This protocol was registered on 15.10.2024 (CRD42024601380)..
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spelling doaj-art-4dab1a704ec94840a624a8e767cb75da2025-08-20T02:34:16ZengWellcomeWellcome Open Research2398-502X2025-05-01910.12688/wellcomeopenres.23278.226799Cognitive bias modification for social anxiety: protocol for a living systematic review of human studies and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]Paulina Schenk0https://orcid.org/0000-0002-5239-1977Virginia Chiocchia1https://orcid.org/0000-0002-6196-3308Hossein Dehdarirad2Janna Hastings3https://orcid.org/0000-0002-3469-4923Claire Stansfield4Toshi Furukawa5https://orcid.org/0000-0003-2159-3776Simon E. Blackwell6https://orcid.org/0000-0002-3313-7084Ava Homiar7https://orcid.org/0000-0001-5772-2475Thomy Tonia8Per Carlbring9https://orcid.org/0000-0002-2172-8813Kelvin Opiepie10Claire Friedrich11https://orcid.org/0000-0002-5841-4324Simonne Wright12Susan Michie13https://orcid.org/0000-0003-0063-6378Georgia Salanti14Richardson Mojica15James Thomas16https://orcid.org/0000-0003-4805-4190Jaycee Kennett17https://orcid.org/0000-0002-7312-8676Andrea Cipriani18Jennifer Potts19Centre for Behaviour Change, University College London, London, UKInstitute of Social and Preventive Medicine, University of Bern, Bern, SwitzerlandEPPI Centre, Social Research Institute, University College London, London, UKInstitute for Implementation Science in Health Care, Faculty of Medicine, University of Zurich, Zurich, SwitzerlandEPPI Centre, Social Research Institute, University College London, London, UKDepartment of Health Promotion and Human Behaviour / School of Public Health, Kyoto University, Kyoto, JapanDepartment of Clinical Psychology and Experimental Psychopathology, Institute of Psychology, University of Göttingen, Göttingen, GermanyDepartment of Psychiatry, University of Oxford, Oxford, England, UKInstitute of Social and Preventive Medicine, University of Bern, Bern, SwitzerlandDepartment of Psychology, Stockholm University, Stockholm, SwedenGlobal Lived Experience Advisory Board, GALENOS, Ogun State, NigeriaDepartment of Psychiatry, University of Oxford, Oxford, England, UKDepartment of Psychiatry, Stellenbosch University, Stellenbosch, South AfricaCentre for Behaviour Change, University College London, London, UKInstitute of Social and Preventive Medicine, University of Bern, Bern, SwitzerlandGlobal Lived Experience Advisory Board, GALENOS, Bacoor, PhilippinesEPPI Centre, Social Research Institute, University College London, London, UKDepartment of Psychiatry, University of Oxford, Oxford, England, UKDepartment of Psychiatry, University of Oxford, Oxford, England, UKDepartment of Psychiatry, University of Oxford, Oxford, England, UKBackground Social anxiety is a heightened fear and discomfort in social situations. Cases of elevated distress and impaired functioning can lead to a clinical diagnosis of social anxiety disorder. Altering cognitive biases associated with social anxiety has been suggested as potentially beneficial; however, little is known about the comparative effectiveness of such interventions. The aim of this living systematic review is to examine the efficacy of cognitive bias modification for reducing social anxiety. Methods We will search multiple electronic databases for randomised controlled trials evaluating the efficacy of cognitive bias modification for people diagnosed with social anxiety and people exposed to a social stressor. The primary outcome will be change in social anxiety related symptoms; secondary outcomes will be changes in social functioning and quality of life and adverse events. Study selection, data extraction and risk of bias assessment will be done by at least two reviewers using pre-defined tools. We will synthesise data from people with social anxiety diagnosis and those subjected to a simulated social stressor separately using random effects meta-analyses. Heterogeneity will be evaluated by investigating characteristics of included studies and we will conduct a network meta-analysis in order to compare the efficacy of subtypes of cognitive bias modification for social anxiety disorder. We will appraise the strength of the evidence for each outcome by reviewing the overall association, internal and external validity, and reporting biases. Where data allows, we will triangulate the evidence from both sources with a multidisciplinary group of experts. We will also descriptively report factors reported to mediate cognitive bias modification, The review will begin in living mode and the database search will be rerun every three months to identify potential new evidence. We will co-produce this review with members of a global lived experience advisory board. This protocol was registered on 15.10.2024 (CRD42024601380)..https://wellcomeopenresearch.org/articles/9-657/v2GALENOS social anxiety cognitive bias modificationeng
spellingShingle Paulina Schenk
Virginia Chiocchia
Hossein Dehdarirad
Janna Hastings
Claire Stansfield
Toshi Furukawa
Simon E. Blackwell
Ava Homiar
Thomy Tonia
Per Carlbring
Kelvin Opiepie
Claire Friedrich
Simonne Wright
Susan Michie
Georgia Salanti
Richardson Mojica
James Thomas
Jaycee Kennett
Andrea Cipriani
Jennifer Potts
Cognitive bias modification for social anxiety: protocol for a living systematic review of human studies and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]
Wellcome Open Research
GALENOS
social anxiety
cognitive bias modification
eng
title Cognitive bias modification for social anxiety: protocol for a living systematic review of human studies and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]
title_full Cognitive bias modification for social anxiety: protocol for a living systematic review of human studies and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]
title_fullStr Cognitive bias modification for social anxiety: protocol for a living systematic review of human studies and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]
title_full_unstemmed Cognitive bias modification for social anxiety: protocol for a living systematic review of human studies and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]
title_short Cognitive bias modification for social anxiety: protocol for a living systematic review of human studies and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]
title_sort cognitive bias modification for social anxiety protocol for a living systematic review of human studies and meta analysis version 2 peer review 2 approved 1 approved with reservations
topic GALENOS
social anxiety
cognitive bias modification
eng
url https://wellcomeopenresearch.org/articles/9-657/v2
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