Assessment of Penetration Depth of Silver Diamine Fluoride in Synthetic Dental Minerals
Dental caries is a prevalent global health issue characterized by the progressive demineralization of dental tissues, which occurs when the balance between demineralization and remineralization processes is disrupted at the tooth level. Silver diamine fluoride (SDF) has gained recognition for its ab...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Inorganics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6740/13/3/81 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850204238197555200 |
|---|---|
| author | Daniella Battaglia Brunna da Silva Nobrega Souza Ana Carla B. C. J. Fernandes Rodrigo França |
| author_facet | Daniella Battaglia Brunna da Silva Nobrega Souza Ana Carla B. C. J. Fernandes Rodrigo França |
| author_sort | Daniella Battaglia |
| collection | DOAJ |
| description | Dental caries is a prevalent global health issue characterized by the progressive demineralization of dental tissues, which occurs when the balance between demineralization and remineralization processes is disrupted at the tooth level. Silver diamine fluoride (SDF) has gained recognition for its ability to arrest caries. However, its interaction with mineralized tissues remains incompletely understood. This study aimed to investigate the chemical interactions between SDF and mineralized bioceramics, using hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) as analogs for enamel and dentin. Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) were employed to identify functional groups and quantify elemental compositions at varying depths. FTIR analysis revealed structural modifications in HA and β-TCP. XPS demonstrated high retention of fluoride, with limited penetration into deeper layers, while silver exhibited deeper penetration. These findings suggest that SDF primarily acts on superficial layers, forming calcium fluoride and silver phosphate as key reaction products. These findings highlight the potential of SDF in managing deep carious lesions by demonstrating its ability to form a protective CaF<sub>2</sub> layer at the surface while allowing deeper penetration of silver ions into mineralized tissues. This dual mechanism may contribute to SDF’s clinical efficacy in arresting caries and preventing further demineralization. |
| format | Article |
| id | doaj-art-4daae90749b145b3a936bf1acc843641 |
| institution | OA Journals |
| issn | 2304-6740 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj-art-4daae90749b145b3a936bf1acc8436412025-08-20T02:11:20ZengMDPI AGInorganics2304-67402025-03-011338110.3390/inorganics13030081Assessment of Penetration Depth of Silver Diamine Fluoride in Synthetic Dental MineralsDaniella Battaglia0Brunna da Silva Nobrega Souza1Ana Carla B. C. J. Fernandes2Rodrigo França3Dental Biomaterials Research Lab, Department of Restorative-Dentistry, College of Dentistry, University of Manitoba, Winnipeg, MB R3E 0W2, CanadaDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos 12245-000, BrazilDental Biomaterials Research Lab, Department of Restorative-Dentistry, College of Dentistry, University of Manitoba, Winnipeg, MB R3E 0W2, CanadaDental Biomaterials Research Lab, Department of Restorative-Dentistry, College of Dentistry, University of Manitoba, Winnipeg, MB R3E 0W2, CanadaDental caries is a prevalent global health issue characterized by the progressive demineralization of dental tissues, which occurs when the balance between demineralization and remineralization processes is disrupted at the tooth level. Silver diamine fluoride (SDF) has gained recognition for its ability to arrest caries. However, its interaction with mineralized tissues remains incompletely understood. This study aimed to investigate the chemical interactions between SDF and mineralized bioceramics, using hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) as analogs for enamel and dentin. Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) were employed to identify functional groups and quantify elemental compositions at varying depths. FTIR analysis revealed structural modifications in HA and β-TCP. XPS demonstrated high retention of fluoride, with limited penetration into deeper layers, while silver exhibited deeper penetration. These findings suggest that SDF primarily acts on superficial layers, forming calcium fluoride and silver phosphate as key reaction products. These findings highlight the potential of SDF in managing deep carious lesions by demonstrating its ability to form a protective CaF<sub>2</sub> layer at the surface while allowing deeper penetration of silver ions into mineralized tissues. This dual mechanism may contribute to SDF’s clinical efficacy in arresting caries and preventing further demineralization.https://www.mdpi.com/2304-6740/13/3/81diamine silver fluoridedental decayhydroxyapatite derivatestopical fluoridessilver compounds |
| spellingShingle | Daniella Battaglia Brunna da Silva Nobrega Souza Ana Carla B. C. J. Fernandes Rodrigo França Assessment of Penetration Depth of Silver Diamine Fluoride in Synthetic Dental Minerals Inorganics diamine silver fluoride dental decay hydroxyapatite derivates topical fluorides silver compounds |
| title | Assessment of Penetration Depth of Silver Diamine Fluoride in Synthetic Dental Minerals |
| title_full | Assessment of Penetration Depth of Silver Diamine Fluoride in Synthetic Dental Minerals |
| title_fullStr | Assessment of Penetration Depth of Silver Diamine Fluoride in Synthetic Dental Minerals |
| title_full_unstemmed | Assessment of Penetration Depth of Silver Diamine Fluoride in Synthetic Dental Minerals |
| title_short | Assessment of Penetration Depth of Silver Diamine Fluoride in Synthetic Dental Minerals |
| title_sort | assessment of penetration depth of silver diamine fluoride in synthetic dental minerals |
| topic | diamine silver fluoride dental decay hydroxyapatite derivates topical fluorides silver compounds |
| url | https://www.mdpi.com/2304-6740/13/3/81 |
| work_keys_str_mv | AT daniellabattaglia assessmentofpenetrationdepthofsilverdiaminefluorideinsyntheticdentalminerals AT brunnadasilvanobregasouza assessmentofpenetrationdepthofsilverdiaminefluorideinsyntheticdentalminerals AT anacarlabcjfernandes assessmentofpenetrationdepthofsilverdiaminefluorideinsyntheticdentalminerals AT rodrigofranca assessmentofpenetrationdepthofsilverdiaminefluorideinsyntheticdentalminerals |