Oncogenic K-Ras Activates p38 to Maintain Colorectal Cancer Cell Proliferation during MEK Inhibition
Background: Colon carcinomas frequently contain activating mutations in the K-ras proto-oncogene. K-ras itself is a poor drug target and drug development efforts have mostly focused on components of the classical Ras-activated MEK/ERK pathway. Here we have studied whether endogenous oncogenic K-ras...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2010-0521 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850106798082621440 |
|---|---|
| author | Winan J. van Houdt Menno T. de Bruijn Benjamin L. Emmink Danielle Raats Frederik J. H. Hoogwater Inne H. M. Borel Rinkes Onno Kranenburg |
| author_facet | Winan J. van Houdt Menno T. de Bruijn Benjamin L. Emmink Danielle Raats Frederik J. H. Hoogwater Inne H. M. Borel Rinkes Onno Kranenburg |
| author_sort | Winan J. van Houdt |
| collection | DOAJ |
| description | Background: Colon carcinomas frequently contain activating mutations in the K-ras proto-oncogene. K-ras itself is a poor drug target and drug development efforts have mostly focused on components of the classical Ras-activated MEK/ERK pathway. Here we have studied whether endogenous oncogenic K-ras affects the dependency of colorectal tumor cells on MEK/ERK signaling. |
| format | Article |
| id | doaj-art-4daa0ec8b6934c30a46edea6cf1b18a1 |
| institution | OA Journals |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-4daa0ec8b6934c30a46edea6cf1b18a12025-08-20T02:38:45ZengWileyCellular Oncology1570-58701875-86062010-01-0132424525710.3233/CLO-2010-0521Oncogenic K-Ras Activates p38 to Maintain Colorectal Cancer Cell Proliferation during MEK InhibitionWinan J. van Houdt0Menno T. de Bruijn1Benjamin L. Emmink2Danielle Raats3Frederik J. H. Hoogwater4Inne H. M. Borel Rinkes5Onno Kranenburg6Department of Surgery, University Medical Center Utrecht, Heidelberglaan, Utrecht, The NetherlandsDepartment of Surgery, University Medical Center Utrecht, Heidelberglaan, Utrecht, The NetherlandsDepartment of Surgery, University Medical Center Utrecht, Heidelberglaan, Utrecht, The NetherlandsDepartment of Surgery, University Medical Center Utrecht, Heidelberglaan, Utrecht, The NetherlandsDepartment of Surgery, University Medical Center Utrecht, Heidelberglaan, Utrecht, The NetherlandsDepartment of Surgery, University Medical Center Utrecht, Heidelberglaan, Utrecht, The NetherlandsDepartment of Surgery, University Medical Center Utrecht, Heidelberglaan, Utrecht, The NetherlandsBackground: Colon carcinomas frequently contain activating mutations in the K-ras proto-oncogene. K-ras itself is a poor drug target and drug development efforts have mostly focused on components of the classical Ras-activated MEK/ERK pathway. Here we have studied whether endogenous oncogenic K-ras affects the dependency of colorectal tumor cells on MEK/ERK signaling.http://dx.doi.org/10.3233/CLO-2010-0521 |
| spellingShingle | Winan J. van Houdt Menno T. de Bruijn Benjamin L. Emmink Danielle Raats Frederik J. H. Hoogwater Inne H. M. Borel Rinkes Onno Kranenburg Oncogenic K-Ras Activates p38 to Maintain Colorectal Cancer Cell Proliferation during MEK Inhibition Cellular Oncology |
| title | Oncogenic K-Ras Activates p38 to Maintain Colorectal Cancer Cell Proliferation during MEK Inhibition |
| title_full | Oncogenic K-Ras Activates p38 to Maintain Colorectal Cancer Cell Proliferation during MEK Inhibition |
| title_fullStr | Oncogenic K-Ras Activates p38 to Maintain Colorectal Cancer Cell Proliferation during MEK Inhibition |
| title_full_unstemmed | Oncogenic K-Ras Activates p38 to Maintain Colorectal Cancer Cell Proliferation during MEK Inhibition |
| title_short | Oncogenic K-Ras Activates p38 to Maintain Colorectal Cancer Cell Proliferation during MEK Inhibition |
| title_sort | oncogenic k ras activates p38 to maintain colorectal cancer cell proliferation during mek inhibition |
| url | http://dx.doi.org/10.3233/CLO-2010-0521 |
| work_keys_str_mv | AT winanjvanhoudt oncogenickrasactivatesp38tomaintaincolorectalcancercellproliferationduringmekinhibition AT mennotdebruijn oncogenickrasactivatesp38tomaintaincolorectalcancercellproliferationduringmekinhibition AT benjaminlemmink oncogenickrasactivatesp38tomaintaincolorectalcancercellproliferationduringmekinhibition AT danielleraats oncogenickrasactivatesp38tomaintaincolorectalcancercellproliferationduringmekinhibition AT frederikjhhoogwater oncogenickrasactivatesp38tomaintaincolorectalcancercellproliferationduringmekinhibition AT innehmborelrinkes oncogenickrasactivatesp38tomaintaincolorectalcancercellproliferationduringmekinhibition AT onnokranenburg oncogenickrasactivatesp38tomaintaincolorectalcancercellproliferationduringmekinhibition |