Genetic profiling and precision skin care: a review
Skin aging is a multifaceted biological phenomenon driven by intrinsic and extrinsic factors, including genetics, hormonal changes, metabolic shifts, and environmental influences. Notably, genetic factors play a significant role, explaining up to 60% of the variability in how individuals age. Genes...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2025.1559510/full |
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| author | Barbara Geusens Diala Haykal |
| author_facet | Barbara Geusens Diala Haykal |
| author_sort | Barbara Geusens |
| collection | DOAJ |
| description | Skin aging is a multifaceted biological phenomenon driven by intrinsic and extrinsic factors, including genetics, hormonal changes, metabolic shifts, and environmental influences. Notably, genetic factors play a significant role, explaining up to 60% of the variability in how individuals age. Genes such as elastin (ELN), filaggrin (FLG), and melanocortin 1 receptor (MC1R) play pivotal roles in processes like elasticity, hydration, and pigmentation, directly impacting both intrinsic and extrinsic aging pathways. Understanding these genetic mechanisms is crucial for advancing personalized anti-aging products and therapies, particularly given the significant variability among individuals and ethnic groups. This review explores the current state of knowledge regarding the genetic determinants of skin aging, highlighting recent discoveries and proposing functional pathways for targeted interventions. Future directions are discussed to highlight the transformative potential of these innovations in clinical and aesthetic dermatology. While genetic factors may account for up to 60% of skin aging variability in specific populations, this figure should be interpreted with caution. It primarily reflects heritability under controlled conditions and does not negate the significant influence of modifiable lifestyle and environmental factors on skin and overall aging. |
| format | Article |
| id | doaj-art-4da7ede8ddbd4e72bd6f38b158ad0600 |
| institution | OA Journals |
| issn | 1664-8021 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj-art-4da7ede8ddbd4e72bd6f38b158ad06002025-08-20T02:32:19ZengFrontiers Media S.A.Frontiers in Genetics1664-80212025-06-011610.3389/fgene.2025.15595101559510Genetic profiling and precision skin care: a reviewBarbara Geusens0Diala Haykal1Nomige, Gent, BelgiumPrivate Practice, Centre Médical Laser Palaiseau, Paris, FranceSkin aging is a multifaceted biological phenomenon driven by intrinsic and extrinsic factors, including genetics, hormonal changes, metabolic shifts, and environmental influences. Notably, genetic factors play a significant role, explaining up to 60% of the variability in how individuals age. Genes such as elastin (ELN), filaggrin (FLG), and melanocortin 1 receptor (MC1R) play pivotal roles in processes like elasticity, hydration, and pigmentation, directly impacting both intrinsic and extrinsic aging pathways. Understanding these genetic mechanisms is crucial for advancing personalized anti-aging products and therapies, particularly given the significant variability among individuals and ethnic groups. This review explores the current state of knowledge regarding the genetic determinants of skin aging, highlighting recent discoveries and proposing functional pathways for targeted interventions. Future directions are discussed to highlight the transformative potential of these innovations in clinical and aesthetic dermatology. While genetic factors may account for up to 60% of skin aging variability in specific populations, this figure should be interpreted with caution. It primarily reflects heritability under controlled conditions and does not negate the significant influence of modifiable lifestyle and environmental factors on skin and overall aging.https://www.frontiersin.org/articles/10.3389/fgene.2025.1559510/fulldermageneticsgenetic profilingmulti-omicsprecision dermatologyskin agingpolygenic risk scores |
| spellingShingle | Barbara Geusens Diala Haykal Genetic profiling and precision skin care: a review Frontiers in Genetics dermagenetics genetic profiling multi-omics precision dermatology skin aging polygenic risk scores |
| title | Genetic profiling and precision skin care: a review |
| title_full | Genetic profiling and precision skin care: a review |
| title_fullStr | Genetic profiling and precision skin care: a review |
| title_full_unstemmed | Genetic profiling and precision skin care: a review |
| title_short | Genetic profiling and precision skin care: a review |
| title_sort | genetic profiling and precision skin care a review |
| topic | dermagenetics genetic profiling multi-omics precision dermatology skin aging polygenic risk scores |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2025.1559510/full |
| work_keys_str_mv | AT barbarageusens geneticprofilingandprecisionskincareareview AT dialahaykal geneticprofilingandprecisionskincareareview |