Effects of repeated low-level red-light therapy on macular retinal thickness and microvascular system in children with myopia
Objective: The objective of the study was to use optical coherence tomography angiography (OCTA) to analyze the effects of repeated low-level red-light (LLLT) therapy on macular retinal thickness and the microvascular system in children with myopia to evaluate the safety of this therapy. Methods: Th...
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| Format: | Article |
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100023006671 |
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| author | Linlin Liu Yuchuan Wang Fang Liu Xinghui Yu Lianfeng Xie Shuxiang Tan Jing Liu Yanfang Liu Jiaxing Huang Shuang Zhang Yiping Jiang |
| author_facet | Linlin Liu Yuchuan Wang Fang Liu Xinghui Yu Lianfeng Xie Shuxiang Tan Jing Liu Yanfang Liu Jiaxing Huang Shuang Zhang Yiping Jiang |
| author_sort | Linlin Liu |
| collection | DOAJ |
| description | Objective: The objective of the study was to use optical coherence tomography angiography (OCTA) to analyze the effects of repeated low-level red-light (LLLT) therapy on macular retinal thickness and the microvascular system in children with myopia to evaluate the safety of this therapy. Methods: This prospective study included 40 school-age children with myopia (80 eyes), aged 7–14 years, who received therapy using a LLLT instrument. At baseline and therapy for 1 month, 3 months, 6 months, all children underwent comprehensive ophthalmological examinations, including slit-lamp examination, uncorrected visual acuity, best-corrected visual acuity, spherical equivalent degree, axial length, and OCTA. The vessel densities of the superficial retinal capillary plexus, macular inner retinal thickness, and full-layer retinal thickness were measured. Results: The macular inner retinal thickness increased at 1 month and remained unchanged thereafter, It differed significantly in nine areas at 1, 3, and 6 months compared to the thicknesses before therapy (P < 0.05); however, we observed no significant differences between the different time points (P > 0.05). The macular full-layer retinal thickness increased at 1 month and remained unchanged thereafter; the changes showed significant differences at 1 month and 3 months compared to before therapy, for the inner nasal region (P < 0.05). The other eight areas showed significant differences at 1, 3, and 6 months compared with before therapy (P < 0.05); however, no significant difference was observed between the different time points after therapy (P > 0.05). The vessel density of the superficial retinal capillary plexus did not differ significantly among the four groups (P > 0.05). Conclusions: LLLT therapy was safe. The school-aged children exhibited macular thickening after LLLT therapy, which had no significant effect on macular microcirculation. |
| format | Article |
| id | doaj-art-4da5933d65aa41fb8f021cb76ebd2244 |
| institution | DOAJ |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-4da5933d65aa41fb8f021cb76ebd22442025-08-20T02:50:05ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-014510393810.1016/j.pdpdt.2023.103938Effects of repeated low-level red-light therapy on macular retinal thickness and microvascular system in children with myopiaLinlin Liu0Yuchuan Wang1Fang Liu2Xinghui Yu3Lianfeng Xie4Shuxiang Tan5Jing Liu6Yanfang Liu7Jiaxing Huang8Shuang Zhang9Yiping Jiang10Department of Ophthalmology, the First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, ChinaXixia County People's Hospital, Nanyang, Henan, China; The First Clinical Medical College of Gannan Medical University, Ganzhou 341000, Jiangxi, ChinaThe First Clinical Medical College of Gannan Medical University, Ganzhou 341000, Jiangxi, ChinaThe First Clinical Medical College of Gannan Medical University, Ganzhou 341000, Jiangxi, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, China; Corresponding author.Objective: The objective of the study was to use optical coherence tomography angiography (OCTA) to analyze the effects of repeated low-level red-light (LLLT) therapy on macular retinal thickness and the microvascular system in children with myopia to evaluate the safety of this therapy. Methods: This prospective study included 40 school-age children with myopia (80 eyes), aged 7–14 years, who received therapy using a LLLT instrument. At baseline and therapy for 1 month, 3 months, 6 months, all children underwent comprehensive ophthalmological examinations, including slit-lamp examination, uncorrected visual acuity, best-corrected visual acuity, spherical equivalent degree, axial length, and OCTA. The vessel densities of the superficial retinal capillary plexus, macular inner retinal thickness, and full-layer retinal thickness were measured. Results: The macular inner retinal thickness increased at 1 month and remained unchanged thereafter, It differed significantly in nine areas at 1, 3, and 6 months compared to the thicknesses before therapy (P < 0.05); however, we observed no significant differences between the different time points (P > 0.05). The macular full-layer retinal thickness increased at 1 month and remained unchanged thereafter; the changes showed significant differences at 1 month and 3 months compared to before therapy, for the inner nasal region (P < 0.05). The other eight areas showed significant differences at 1, 3, and 6 months compared with before therapy (P < 0.05); however, no significant difference was observed between the different time points after therapy (P > 0.05). The vessel density of the superficial retinal capillary plexus did not differ significantly among the four groups (P > 0.05). Conclusions: LLLT therapy was safe. The school-aged children exhibited macular thickening after LLLT therapy, which had no significant effect on macular microcirculation.http://www.sciencedirect.com/science/article/pii/S1572100023006671Repeated low-level red-light therapyMacular microcirculationSafetyOCTLow Level light |
| spellingShingle | Linlin Liu Yuchuan Wang Fang Liu Xinghui Yu Lianfeng Xie Shuxiang Tan Jing Liu Yanfang Liu Jiaxing Huang Shuang Zhang Yiping Jiang Effects of repeated low-level red-light therapy on macular retinal thickness and microvascular system in children with myopia Photodiagnosis and Photodynamic Therapy Repeated low-level red-light therapy Macular microcirculation Safety OCT Low Level light |
| title | Effects of repeated low-level red-light therapy on macular retinal thickness and microvascular system in children with myopia |
| title_full | Effects of repeated low-level red-light therapy on macular retinal thickness and microvascular system in children with myopia |
| title_fullStr | Effects of repeated low-level red-light therapy on macular retinal thickness and microvascular system in children with myopia |
| title_full_unstemmed | Effects of repeated low-level red-light therapy on macular retinal thickness and microvascular system in children with myopia |
| title_short | Effects of repeated low-level red-light therapy on macular retinal thickness and microvascular system in children with myopia |
| title_sort | effects of repeated low level red light therapy on macular retinal thickness and microvascular system in children with myopia |
| topic | Repeated low-level red-light therapy Macular microcirculation Safety OCT Low Level light |
| url | http://www.sciencedirect.com/science/article/pii/S1572100023006671 |
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