Central retinal vein occlusion: A patient with systemic sclerosis
Introduction. Scleroderma (systemic sclerosis) is a severe chronic connective tissue disease, which results in involvement of numerous internal organs. Changes in the eye are the consequences of organ-specific manifestations of scleroderma or adverse effects of immunosuppressive treatment applied. C...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2016-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600073K.pdf |
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| author | Karadžić Jelena Radosavljević Aleksandra Kovačević Igor |
| author_facet | Karadžić Jelena Radosavljević Aleksandra Kovačević Igor |
| author_sort | Karadžić Jelena |
| collection | DOAJ |
| description | Introduction. Scleroderma (systemic sclerosis) is a severe chronic connective tissue disease, which results in involvement of numerous internal organs. Changes in the eye are the consequences of organ-specific manifestations of scleroderma or adverse effects of immunosuppressive treatment applied. Case report. We reported a 42-year-old woman with systemic sclerosis and acute deterioration of vision in the left eye, with visual acuity 0.9. After thorough clinical examination, including fluorescein angiography and optical coherence tomography, the diagnosis of nonischemic central retinal vein occlusion was made. Further biochemical, rheumatological and immunological investigation, apart from inactive systemic sclerosis, showed normal findings. Therefore, the cause of central retinal vein occlusion could only be attributed to the microvascular changes in systemic sclerosis. After three months, visual acuity deteriorated to 0.6 due to the development of cystoid macular edema. The patient received intravitreal injection of bevacizumab and after a single dose visual acuity improved to 0.9. After a 6- month follow-up, macular edema resolved and visual acuity stabilized. Conclusion. According to our knowledge and current data from the literature, central retinal vein occlusion is a rare vision threatening manifestation of scleroderma. There are only few published case reports on central vein occlusion in scleroderma patients. Examination of the ocular fundus is recommended for evaluation of vascular disease in patients with systemic sclerosis. |
| format | Article |
| id | doaj-art-4da58b2a24cd42d4b3f08951745f3629 |
| institution | Kabale University |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-4da58b2a24cd42d4b3f08951745f36292025-08-20T03:36:22ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202016-01-0173986887210.2298/VSP141028073K0042-84501600073KCentral retinal vein occlusion: A patient with systemic sclerosisKaradžić Jelena0Radosavljević Aleksandra1Kovačević Igor2Clinical Centre of Serbia, Clinic for Eye Diseases, BelgradeClinical Centre of Serbia, Clinic for Eye Diseases, Belgrade + Faculty of Medicine, BelgradeClinical Centre of Serbia, Clinic for Eye Diseases, Belgrade + Faculty of Medicine, BelgradeIntroduction. Scleroderma (systemic sclerosis) is a severe chronic connective tissue disease, which results in involvement of numerous internal organs. Changes in the eye are the consequences of organ-specific manifestations of scleroderma or adverse effects of immunosuppressive treatment applied. Case report. We reported a 42-year-old woman with systemic sclerosis and acute deterioration of vision in the left eye, with visual acuity 0.9. After thorough clinical examination, including fluorescein angiography and optical coherence tomography, the diagnosis of nonischemic central retinal vein occlusion was made. Further biochemical, rheumatological and immunological investigation, apart from inactive systemic sclerosis, showed normal findings. Therefore, the cause of central retinal vein occlusion could only be attributed to the microvascular changes in systemic sclerosis. After three months, visual acuity deteriorated to 0.6 due to the development of cystoid macular edema. The patient received intravitreal injection of bevacizumab and after a single dose visual acuity improved to 0.9. After a 6- month follow-up, macular edema resolved and visual acuity stabilized. Conclusion. According to our knowledge and current data from the literature, central retinal vein occlusion is a rare vision threatening manifestation of scleroderma. There are only few published case reports on central vein occlusion in scleroderma patients. Examination of the ocular fundus is recommended for evaluation of vascular disease in patients with systemic sclerosis.http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600073K.pdfscleroderma, systemicretinal vein occlusiondiagnosisangiogenesis inhibitorstreatment outcome |
| spellingShingle | Karadžić Jelena Radosavljević Aleksandra Kovačević Igor Central retinal vein occlusion: A patient with systemic sclerosis Vojnosanitetski Pregled scleroderma, systemic retinal vein occlusion diagnosis angiogenesis inhibitors treatment outcome |
| title | Central retinal vein occlusion: A patient with systemic sclerosis |
| title_full | Central retinal vein occlusion: A patient with systemic sclerosis |
| title_fullStr | Central retinal vein occlusion: A patient with systemic sclerosis |
| title_full_unstemmed | Central retinal vein occlusion: A patient with systemic sclerosis |
| title_short | Central retinal vein occlusion: A patient with systemic sclerosis |
| title_sort | central retinal vein occlusion a patient with systemic sclerosis |
| topic | scleroderma, systemic retinal vein occlusion diagnosis angiogenesis inhibitors treatment outcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600073K.pdf |
| work_keys_str_mv | AT karadzicjelena centralretinalveinocclusionapatientwithsystemicsclerosis AT radosavljevicaleksandra centralretinalveinocclusionapatientwithsystemicsclerosis AT kovacevicigor centralretinalveinocclusionapatientwithsystemicsclerosis |