Phenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular Degeneration
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2025-07-01
|
| Series: | ACS Omega |
| Online Access: | https://doi.org/10.1021/acsomega.5c02227 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849731853869645824 |
|---|---|
| author | Kyung Hae Lee Bongkyun Park Eun Hyeon Jeong Gyu Sang Yoo Young Sook Kim Linhua Jin Abdul Fahim Samadi Hyeon Woo Seong Jong Mo Ryu Jaeeun Jung Gwang-Hwan Ahn Jin Sook Kim Dong-Won Choo Jay M. Stewart Dong Hyun Jee Wan Jin Jahng |
| author_facet | Kyung Hae Lee Bongkyun Park Eun Hyeon Jeong Gyu Sang Yoo Young Sook Kim Linhua Jin Abdul Fahim Samadi Hyeon Woo Seong Jong Mo Ryu Jaeeun Jung Gwang-Hwan Ahn Jin Sook Kim Dong-Won Choo Jay M. Stewart Dong Hyun Jee Wan Jin Jahng |
| author_sort | Kyung Hae Lee |
| collection | DOAJ |
| format | Article |
| id | doaj-art-4da44934e3074964a46d4cab3af3cfe7 |
| institution | DOAJ |
| issn | 2470-1343 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | ACS Omega |
| spelling | doaj-art-4da44934e3074964a46d4cab3af3cfe72025-08-20T03:08:24ZengAmerican Chemical SocietyACS Omega2470-13432025-07-011028304673048810.1021/acsomega.5c02227Phenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular DegenerationKyung Hae Lee0Bongkyun Park1Eun Hyeon Jeong2Gyu Sang Yoo3Young Sook Kim4Linhua Jin5Abdul Fahim Samadi6Hyeon Woo Seong7Jong Mo Ryu8Jaeeun Jung9Gwang-Hwan Ahn10Jin Sook Kim11Dong-Won Choo12Jay M. Stewart13Dong Hyun Jee14Wan Jin Jahng15Department of Ophthalmology, Julia Laboratory, Suwon, KoreaKorea Institute of Oriental Medicine, Daejeon, KoreaDepartment of Ophthalmology, Julia Laboratory, Suwon, KoreaDepartment of Ophthalmology, Julia Laboratory, Suwon, KoreaKorea Institute of Oriental Medicine, Daejeon, KoreaDepartment of Ophthalmology, Julia Laboratory, Suwon, KoreaDepartment of Drug Discoveries, Julia Eye Institute, Suwon, KoreaDepartment of Ophthalmology, Julia Laboratory, Suwon, KoreaDepartment of Ophthalmology, Julia Laboratory, Suwon, KoreaSweet Persimmon Research Institute, Gyeongsangnam-do Agricultural Research and Extension Services, Gimhae, KoreaSweet Persimmon Research Institute, Gyeongsangnam-do Agricultural Research and Extension Services, Gimhae, KoreaDepartment of Ophthalmology, Julia Laboratory, Suwon, KoreaDepartment of Bioinformatics, Bio Campus of Korea Polytechnic University, Nonsan, KoreaDepartment of Ophthalmology, School of Medicine, University of California, San Francisco, California, United StatesDepartment of Ophthalmology and Visual Science, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, KoreaDepartment of Ophthalmology, Julia Laboratory, Suwon, Koreahttps://doi.org/10.1021/acsomega.5c02227 |
| spellingShingle | Kyung Hae Lee Bongkyun Park Eun Hyeon Jeong Gyu Sang Yoo Young Sook Kim Linhua Jin Abdul Fahim Samadi Hyeon Woo Seong Jong Mo Ryu Jaeeun Jung Gwang-Hwan Ahn Jin Sook Kim Dong-Won Choo Jay M. Stewart Dong Hyun Jee Wan Jin Jahng Phenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular Degeneration ACS Omega |
| title | Phenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular Degeneration |
| title_full | Phenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular Degeneration |
| title_fullStr | Phenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular Degeneration |
| title_full_unstemmed | Phenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular Degeneration |
| title_short | Phenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular Degeneration |
| title_sort | phenotypic drug discovery platform by quantitative high throughput screening identifies antiapoptotic molecules in a zebrafish model of age related macular degeneration |
| url | https://doi.org/10.1021/acsomega.5c02227 |
| work_keys_str_mv | AT kyunghaelee phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT bongkyunpark phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT eunhyeonjeong phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT gyusangyoo phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT youngsookkim phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT linhuajin phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT abdulfahimsamadi phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT hyeonwooseong phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT jongmoryu phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT jaeeunjung phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT gwanghwanahn phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT jinsookkim phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT dongwonchoo phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT jaymstewart phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT donghyunjee phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration AT wanjinjahng phenotypicdrugdiscoveryplatformbyquantitativehighthroughputscreeningidentifiesantiapoptoticmoleculesinazebrafishmodelofagerelatedmaculardegeneration |