Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver Disease
Background and aims. There is growing evidence that white adipose tissue is an important contributor in the pathogenesis of alcoholic liver disease (ALD). We investigated serum concentrations of total adiponectin (Acrp30), leptin, and resistin in patients with chronic alcohol abuse and different gra...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/148526 |
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| author | Beata Kasztelan-Szczerbinska Agata Surdacka Maria Slomka Jacek Rolinski Krzysztof Celinski Agata Smolen Mariusz Szczerbinski |
| author_facet | Beata Kasztelan-Szczerbinska Agata Surdacka Maria Slomka Jacek Rolinski Krzysztof Celinski Agata Smolen Mariusz Szczerbinski |
| author_sort | Beata Kasztelan-Szczerbinska |
| collection | DOAJ |
| description | Background and aims. There is growing evidence that white adipose tissue is an important contributor in the pathogenesis of alcoholic liver disease (ALD). We investigated serum concentrations of total adiponectin (Acrp30), leptin, and resistin in patients with chronic alcohol abuse and different grades of liver dysfunction, as well as ALD complications. Materials and Methods. One hundred forty-seven consecutive inpatients with ALD were prospectively recruited. The evaluation of plasma adipokine levels was performed using immunoenzymatic ELISA tests. Multivariable logistic regression was applied in order to select independent predictors of advanced liver dysfunction and the disease complications. Results. Acrp30 and resistin levels were significantly higher in patients with ALD than in controls. Lower leptin levels in females with ALD compared to controls, but no significant differences in leptin concentrations in males, were found. High serum Acrp30 level revealed an independent association with advanced liver dysfunction, as well as the development of ALD complications, that is, ascites and hepatic encephalopathy. Conclusion. Gender-related differences in serum leptin concentrations may influence the ALD course, different in females compared with males. Serum Acrp30 level may serve as a potential prognostic indicator for patients with ALD. |
| format | Article |
| id | doaj-art-4da331b5fc4e4e94b779b567711b7252 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4da331b5fc4e4e94b779b567711b72522025-02-03T00:59:28ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/148526148526Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver DiseaseBeata Kasztelan-Szczerbinska0Agata Surdacka1Maria Slomka2Jacek Rolinski3Krzysztof Celinski4Agata Smolen5Mariusz Szczerbinski6Department of Gastroenterology with Endoscopy Unit, Medical University of Lublin, 8 Jaczewski Street, 20-954 Lublin, PolandDepartment of Clinical Immunology, Medical University of Lublin, 4A Chodzki Street, 20-093 Lublin, PolandDepartment of Gastroenterology with Endoscopy Unit, Medical University of Lublin, 8 Jaczewski Street, 20-954 Lublin, PolandDepartment of Clinical Immunology, Medical University of Lublin, 4A Chodzki Street, 20-093 Lublin, PolandDepartment of Gastroenterology with Endoscopy Unit, Medical University of Lublin, 8 Jaczewski Street, 20-954 Lublin, PolandDepartment of Mathematics and Biostatistics, Medical University of Lublin, 4 Jaczewski Street, 20-090 Lublin, PolandDepartment of Gastroenterology with Endoscopy Unit, Medical University of Lublin, 8 Jaczewski Street, 20-954 Lublin, PolandBackground and aims. There is growing evidence that white adipose tissue is an important contributor in the pathogenesis of alcoholic liver disease (ALD). We investigated serum concentrations of total adiponectin (Acrp30), leptin, and resistin in patients with chronic alcohol abuse and different grades of liver dysfunction, as well as ALD complications. Materials and Methods. One hundred forty-seven consecutive inpatients with ALD were prospectively recruited. The evaluation of plasma adipokine levels was performed using immunoenzymatic ELISA tests. Multivariable logistic regression was applied in order to select independent predictors of advanced liver dysfunction and the disease complications. Results. Acrp30 and resistin levels were significantly higher in patients with ALD than in controls. Lower leptin levels in females with ALD compared to controls, but no significant differences in leptin concentrations in males, were found. High serum Acrp30 level revealed an independent association with advanced liver dysfunction, as well as the development of ALD complications, that is, ascites and hepatic encephalopathy. Conclusion. Gender-related differences in serum leptin concentrations may influence the ALD course, different in females compared with males. Serum Acrp30 level may serve as a potential prognostic indicator for patients with ALD.http://dx.doi.org/10.1155/2013/148526 |
| spellingShingle | Beata Kasztelan-Szczerbinska Agata Surdacka Maria Slomka Jacek Rolinski Krzysztof Celinski Agata Smolen Mariusz Szczerbinski Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver Disease Mediators of Inflammation |
| title | Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver Disease |
| title_full | Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver Disease |
| title_fullStr | Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver Disease |
| title_full_unstemmed | Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver Disease |
| title_short | Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver Disease |
| title_sort | association of serum adiponectin leptin and resistin concentrations with the severity of liver dysfunction and the disease complications in alcoholic liver disease |
| url | http://dx.doi.org/10.1155/2013/148526 |
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