Integron-Mediated Antimicrobial Resistance and Virulence Factors in <i>Salmonella</i> Typhimurium Isolated from Poultry

Integron-Mediated Antimicrobial Resistance and Virulence Factors in <i>Salmonella</i> Typhimurium Isolated from Poultry

This study investigates antimicrobial-resistant (AMR) <i>Salmonella</i> Typhimurium in poultry, focusing on how class I integrons contribute to AMR and virulence. Using whole genome sequencing, researchers analyzed 26 <i>S.</i> Typhimurium isolates from U.S. poultry, finding...

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Bibliographic Details
Main Authors: Elizabeth Kim, Nora Jean Nealon, Katherine A. Murray, Cydney Jardine, Roberta Magnuson, Sangeeta Rao
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Animals
Subjects:
poultry
integrons
virulence factors
<i>Salmonella</i> Typhimurium
antimicrobial resistance
Online Access:https://www.mdpi.com/2076-2615/14/23/3483
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Summary:This study investigates antimicrobial-resistant (AMR) <i>Salmonella</i> Typhimurium in poultry, focusing on how class I integrons contribute to AMR and virulence. Using whole genome sequencing, researchers analyzed 26 <i>S.</i> Typhimurium isolates from U.S. poultry, finding that three isolates contained integrons (1000 base pairs each). These integron-positive isolates exhibited significantly higher resistance to beta-lactams, phenicols, and tetracyclines compared to integron-free isolates (<i>p</i> = 0.004, 0.009, and 0.02, respectively) and harbored genes like <i>ges</i>, <i>imp</i>, and <i>oxa</i>, which are linked to extended-spectrum beta-lactamase resistance. Most AMR gene classes (64%) were chromosome-based, with integron-positive isolates showing a broader array of resistance genes, including <i>catB</i> and <i>tetA</i>. Integron-bearing isolates had higher occurrences of bacteriocin genes and specific AMR genes like aminoglycoside and beta-lactam resistance genes, while integron-free isolates had more fimbrial and pilus genes. The presence of integrons may trend with increased AMR genes and virulence factors, highlighting the role of integron screening in enhancing AMR surveillance and reducing the need for high-priority antimicrobial treatments in poultry. These findings could support better AMR stewardship practices in poultry production, potentially lowering infection risks in humans and livestock.
ISSN:2076-2615

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