Clinical and laboratory predictors of survival for pediatric patients on non-postcardiotomy extracorporeal membrane oxygenation (ECMO)
Extracorporeal membrane oxygenation (ECMO) is used in pediatric patients with severe cardiopulmonary failure who do not respond to conventional therapy; only a few studies have been conducted in Turkey. We present the experience of pediatric ECMO with the aim of showing factors affecting mort...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2020-02-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/406 |
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| author | Güntülü Şık Asuman Demirbuğa Agageldi Annayev Bahar Temur Selim Aydın Halil İbrahim Demir Ersin Erek Agop Çıtak |
| author_facet | Güntülü Şık Asuman Demirbuğa Agageldi Annayev Bahar Temur Selim Aydın Halil İbrahim Demir Ersin Erek Agop Çıtak |
| author_sort | Güntülü Şık |
| collection | DOAJ |
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Extracorporeal membrane oxygenation (ECMO) is used in pediatric patients with severe cardiopulmonary failure who do not respond to conventional therapy; only a few studies have been conducted in Turkey. We present the experience of pediatric ECMO with the aim of showing factors affecting mortality. We retrospectively reviewed our ECMO database to identify patients who received ECMO from October 2015 to March 2018. Our population comprised 30 pediatric patients. The mean patient age was 41.31±53.35 months and 17 (56.7%) patients were male. The median duration of ECMO support was 8.9 (6.6-10.8) days. The rates of successful ECMO weaning and survival to discharge were 70.0% (n=21) and 66.7% (n=20), respectively. Indications for ECMO were respiratory failure (40.0%), cardiac failure (33.3%), and sepsis (26.7%). We found that pre-cannulation values of pH (p=0.034), leukocytes (p=0.029), C-reactive protein (p=0.045), creatinine (p=0.047), chloride (p=0.001) and post-cannulation pH (p=0.0001), bicarbonate (p=0.014), lactate (p=0.002), chloride (p=0.0001) were associated with mortality. The results showed that preexisting sepsis and renal conditions contributed to poor outcomes. Indications, ECMO onset time, and pre- and post-cannulation laboratory values such as leukocytes, CRP, creatinine, bicarbonate, lactate, and chloride are factors that affect outcomes.
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| format | Article |
| id | doaj-art-4d988af091904a08a6657f8a68234e39 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2020-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-4d988af091904a08a6657f8a68234e392025-08-20T02:01:47ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212020-02-0162110.24953/turkjped.2020.01.004Clinical and laboratory predictors of survival for pediatric patients on non-postcardiotomy extracorporeal membrane oxygenation (ECMO)Güntülü Şık0Asuman Demirbuğa1Agageldi Annayev2Bahar Temur3Selim Aydın4Halil İbrahim Demir5Ersin Erek6Agop Çıtak7Departments of Pediatric Intensive Care, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Turkey.Departments of Pediatric Intensive Care, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Turkey.Departments of Pediatric Intensive Care, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Turkey.Departments of Cardiovascular Surgery, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Turkey.Departments of Cardiovascular Surgery, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Turkey.Departments of Pediatric Cardiology, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Turkey.Departments of Cardiovascular Surgery, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Turkey.Departments of Pediatric Intensive Care, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Turkey. Extracorporeal membrane oxygenation (ECMO) is used in pediatric patients with severe cardiopulmonary failure who do not respond to conventional therapy; only a few studies have been conducted in Turkey. We present the experience of pediatric ECMO with the aim of showing factors affecting mortality. We retrospectively reviewed our ECMO database to identify patients who received ECMO from October 2015 to March 2018. Our population comprised 30 pediatric patients. The mean patient age was 41.31±53.35 months and 17 (56.7%) patients were male. The median duration of ECMO support was 8.9 (6.6-10.8) days. The rates of successful ECMO weaning and survival to discharge were 70.0% (n=21) and 66.7% (n=20), respectively. Indications for ECMO were respiratory failure (40.0%), cardiac failure (33.3%), and sepsis (26.7%). We found that pre-cannulation values of pH (p=0.034), leukocytes (p=0.029), C-reactive protein (p=0.045), creatinine (p=0.047), chloride (p=0.001) and post-cannulation pH (p=0.0001), bicarbonate (p=0.014), lactate (p=0.002), chloride (p=0.0001) were associated with mortality. The results showed that preexisting sepsis and renal conditions contributed to poor outcomes. Indications, ECMO onset time, and pre- and post-cannulation laboratory values such as leukocytes, CRP, creatinine, bicarbonate, lactate, and chloride are factors that affect outcomes. https://turkjpediatr.org/article/view/406chlorideextracorporeal membrane oxygenationlactatepediatric intensive care |
| spellingShingle | Güntülü Şık Asuman Demirbuğa Agageldi Annayev Bahar Temur Selim Aydın Halil İbrahim Demir Ersin Erek Agop Çıtak Clinical and laboratory predictors of survival for pediatric patients on non-postcardiotomy extracorporeal membrane oxygenation (ECMO) The Turkish Journal of Pediatrics chloride extracorporeal membrane oxygenation lactate pediatric intensive care |
| title | Clinical and laboratory predictors of survival for pediatric patients on non-postcardiotomy extracorporeal membrane oxygenation (ECMO) |
| title_full | Clinical and laboratory predictors of survival for pediatric patients on non-postcardiotomy extracorporeal membrane oxygenation (ECMO) |
| title_fullStr | Clinical and laboratory predictors of survival for pediatric patients on non-postcardiotomy extracorporeal membrane oxygenation (ECMO) |
| title_full_unstemmed | Clinical and laboratory predictors of survival for pediatric patients on non-postcardiotomy extracorporeal membrane oxygenation (ECMO) |
| title_short | Clinical and laboratory predictors of survival for pediatric patients on non-postcardiotomy extracorporeal membrane oxygenation (ECMO) |
| title_sort | clinical and laboratory predictors of survival for pediatric patients on non postcardiotomy extracorporeal membrane oxygenation ecmo |
| topic | chloride extracorporeal membrane oxygenation lactate pediatric intensive care |
| url | https://turkjpediatr.org/article/view/406 |
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