Erythroferron: Modern Concepts of Its Role in Iron Metabolism Regulation
The article presents the results of experimental and clinical studies evaluating the importance of supposed erythroid regulators of hepcidin levels and mechanism of their action. It demonstrates that the role of growth differentiation factor 15 and twisted gastrulation protein homolog 1 in regulatio...
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| Format: | Article |
| Language: | Russian |
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Practical Medicine Publishing House
2017-01-01
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| Series: | Клиническая онкогематология |
| Subjects: | |
| Online Access: | http://bloodjournal.ru/wp-content/uploads/2017/01/3-1.pdf |
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| author | VT Sakhin NV Kremneva AV Gordienko OA Rukavitsyn |
| author_facet | VT Sakhin NV Kremneva AV Gordienko OA Rukavitsyn |
| author_sort | VT Sakhin |
| collection | DOAJ |
| description | The article presents the results of experimental and clinical studies evaluating the importance of supposed erythroid regulators of hepcidin levels and mechanism of their action. It demonstrates that the role of growth differentiation factor 15 and twisted gastrulation protein homolog 1 in regulation of hepcidin levels in humans has not been confirmed yet. The data confirming the importance of erythroferron in the pathogenesis of anemia related to blood loss, hemolysis, and hereditary anemias with ineffective erythropoiesis are presented. The studies demonstrated that erythroferron plays the greatest role in the regulation of hepcidin levels in pathological conditions and at stress and does not play a leading role in erythropoiesis under normal conditions. Erythroferron suppresses the hepcidin synthesis by affecting the liver cells directly through an unknown receptor cellular pathway |
| format | Article |
| id | doaj-art-4d9839672e7e4096b3d6f17b22e63d07 |
| institution | DOAJ |
| issn | 1997-6933 2500-2139 |
| language | Russian |
| publishDate | 2017-01-01 |
| publisher | Practical Medicine Publishing House |
| record_format | Article |
| series | Клиническая онкогематология |
| spelling | doaj-art-4d9839672e7e4096b3d6f17b22e63d072025-08-20T03:19:32ZrusPractical Medicine Publishing HouseКлиническая онкогематология1997-69332500-21392017-01-01101252810.21320/2500-2139-2017-10-1-25-28Erythroferron: Modern Concepts of Its Role in Iron Metabolism RegulationVT Sakhin0NV Kremneva1AV Gordienko2OA Rukavitsyn3Military Clinical Hospital No. 1586 under the Ministry of Defense of Russia, 4 Mashtakova str., Podol’sk, Moscow Oblast, Russian Federation, 142110Military Clinical Hospital No. 1586 under the Ministry of Defense of Russia, 4 Mashtakova str., Podol’sk, Moscow Oblast, Russian Federation, 142110SM Kirov Military Medical Academy, 6 Akademika Lebedeva str., Saint Petersburg, Russian Federation, 194044NN Burdenko Principal Military Clinical Hospital under the Ministry of Defense of Russia, 3 Gospital’naya pl., Moscow, Russian Federation, 105229The article presents the results of experimental and clinical studies evaluating the importance of supposed erythroid regulators of hepcidin levels and mechanism of their action. It demonstrates that the role of growth differentiation factor 15 and twisted gastrulation protein homolog 1 in regulation of hepcidin levels in humans has not been confirmed yet. The data confirming the importance of erythroferron in the pathogenesis of anemia related to blood loss, hemolysis, and hereditary anemias with ineffective erythropoiesis are presented. The studies demonstrated that erythroferron plays the greatest role in the regulation of hepcidin levels in pathological conditions and at stress and does not play a leading role in erythropoiesis under normal conditions. Erythroferron suppresses the hepcidin synthesis by affecting the liver cells directly through an unknown receptor cellular pathwayhttp://bloodjournal.ru/wp-content/uploads/2017/01/3-1.pdfanemia of chronic diseasehepcidinerythroferron |
| spellingShingle | VT Sakhin NV Kremneva AV Gordienko OA Rukavitsyn Erythroferron: Modern Concepts of Its Role in Iron Metabolism Regulation Клиническая онкогематология anemia of chronic disease hepcidin erythroferron |
| title | Erythroferron: Modern Concepts of Its Role in Iron Metabolism Regulation |
| title_full | Erythroferron: Modern Concepts of Its Role in Iron Metabolism Regulation |
| title_fullStr | Erythroferron: Modern Concepts of Its Role in Iron Metabolism Regulation |
| title_full_unstemmed | Erythroferron: Modern Concepts of Its Role in Iron Metabolism Regulation |
| title_short | Erythroferron: Modern Concepts of Its Role in Iron Metabolism Regulation |
| title_sort | erythroferron modern concepts of its role in iron metabolism regulation |
| topic | anemia of chronic disease hepcidin erythroferron |
| url | http://bloodjournal.ru/wp-content/uploads/2017/01/3-1.pdf |
| work_keys_str_mv | AT vtsakhin erythroferronmodernconceptsofitsroleinironmetabolismregulation AT nvkremneva erythroferronmodernconceptsofitsroleinironmetabolismregulation AT avgordienko erythroferronmodernconceptsofitsroleinironmetabolismregulation AT oarukavitsyn erythroferronmodernconceptsofitsroleinironmetabolismregulation |