C1q Levels: A Reliable Biomarker for Differentiating Active and Latent Tuberculosis Infection
Background: Tuberculosis (TB) poses a significant public health challenge, particularly because it can exist in an asymptomatic latent phase. Latent TB infection indicates the presence of Mycobacterium tuberculosis without clinical symptoms. Effectively distinguishing between active and latent TB is...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | International Journal of Mycobacteriology |
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| Online Access: | https://journals.lww.com/10.4103/ijmy.ijmy_194_24 |
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| author | Sepideh Darougar Afshin Moniri Parvaneh Baghaei Esmaeil Mortaz Makan Sadr Arad Moniri Majid Marjani Payam Tabarsi |
| author_facet | Sepideh Darougar Afshin Moniri Parvaneh Baghaei Esmaeil Mortaz Makan Sadr Arad Moniri Majid Marjani Payam Tabarsi |
| author_sort | Sepideh Darougar |
| collection | DOAJ |
| description | Background:
Tuberculosis (TB) poses a significant public health challenge, particularly because it can exist in an asymptomatic latent phase. Latent TB infection indicates the presence of Mycobacterium tuberculosis without clinical symptoms. Effectively distinguishing between active and latent TB is essential, especially in regions with high TB prevalence, as it may help reduce transmission rates. This study aims to evaluate C1q as a potential biomarker for differentiating active TB from latent forms.
Methods:
This prospective cross-sectional study was conducted from January 2017 to February 2018, involving HIV-negative adults aged 18 and older attending TB clinics. Participants were categorized based on clinical symptoms, imaging results, and laboratory tests into active or latent TB. Blood samples were collected to assess serum C1q levels, which were then compared between the two groups.
Results:
Out of 81 patients referred for TB evaluation, 38 were diagnosed with active TB. The overall median C1q level was 6.46 μg/ml (interquartile range 4.66–10). The active TB group exhibited significantly elevated C1q levels (10.21 μg/ml) compared to the latent TB group (6.03 μg/ml, P < 0.001). The area under the receiver operating characteristic curve for C1q in distinguishing active from latent TB was 0.74 (95% confidence interval, 0.63–0.85), with sensitivity varying between 61% and 82% at different threshold values.
Conclusions:
C1q shows potential as a reliable and easily obtainable biomarker for differentiating active TB from latent infection, demonstrating high sensitivity. These results underscore the need for further research to explore the clinical application of C1q in TB diagnostics. |
| format | Article |
| id | doaj-art-4d97ae52b0454041b60fd69a9bceee9b |
| institution | DOAJ |
| issn | 2212-5531 2212-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Mycobacteriology |
| spelling | doaj-art-4d97ae52b0454041b60fd69a9bceee9b2025-08-20T02:45:28ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2024-12-0113440440910.4103/ijmy.ijmy_194_24C1q Levels: A Reliable Biomarker for Differentiating Active and Latent Tuberculosis InfectionSepideh DarougarAfshin MoniriParvaneh BaghaeiEsmaeil MortazMakan SadrArad MoniriMajid MarjaniPayam TabarsiBackground: Tuberculosis (TB) poses a significant public health challenge, particularly because it can exist in an asymptomatic latent phase. Latent TB infection indicates the presence of Mycobacterium tuberculosis without clinical symptoms. Effectively distinguishing between active and latent TB is essential, especially in regions with high TB prevalence, as it may help reduce transmission rates. This study aims to evaluate C1q as a potential biomarker for differentiating active TB from latent forms. Methods: This prospective cross-sectional study was conducted from January 2017 to February 2018, involving HIV-negative adults aged 18 and older attending TB clinics. Participants were categorized based on clinical symptoms, imaging results, and laboratory tests into active or latent TB. Blood samples were collected to assess serum C1q levels, which were then compared between the two groups. Results: Out of 81 patients referred for TB evaluation, 38 were diagnosed with active TB. The overall median C1q level was 6.46 μg/ml (interquartile range 4.66–10). The active TB group exhibited significantly elevated C1q levels (10.21 μg/ml) compared to the latent TB group (6.03 μg/ml, P < 0.001). The area under the receiver operating characteristic curve for C1q in distinguishing active from latent TB was 0.74 (95% confidence interval, 0.63–0.85), with sensitivity varying between 61% and 82% at different threshold values. Conclusions: C1q shows potential as a reliable and easily obtainable biomarker for differentiating active TB from latent infection, demonstrating high sensitivity. These results underscore the need for further research to explore the clinical application of C1q in TB diagnostics.https://journals.lww.com/10.4103/ijmy.ijmy_194_24active tuberculosisbiomarkerc1qlatent tuberculosistuberculosis |
| spellingShingle | Sepideh Darougar Afshin Moniri Parvaneh Baghaei Esmaeil Mortaz Makan Sadr Arad Moniri Majid Marjani Payam Tabarsi C1q Levels: A Reliable Biomarker for Differentiating Active and Latent Tuberculosis Infection International Journal of Mycobacteriology active tuberculosis biomarker c1q latent tuberculosis tuberculosis |
| title | C1q Levels: A Reliable Biomarker for Differentiating Active and Latent Tuberculosis Infection |
| title_full | C1q Levels: A Reliable Biomarker for Differentiating Active and Latent Tuberculosis Infection |
| title_fullStr | C1q Levels: A Reliable Biomarker for Differentiating Active and Latent Tuberculosis Infection |
| title_full_unstemmed | C1q Levels: A Reliable Biomarker for Differentiating Active and Latent Tuberculosis Infection |
| title_short | C1q Levels: A Reliable Biomarker for Differentiating Active and Latent Tuberculosis Infection |
| title_sort | c1q levels a reliable biomarker for differentiating active and latent tuberculosis infection |
| topic | active tuberculosis biomarker c1q latent tuberculosis tuberculosis |
| url | https://journals.lww.com/10.4103/ijmy.ijmy_194_24 |
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