Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination
Background. Although rare, adverse events may associate with anti-poliovirus vaccination thus possibly hampering global polio eradication worldwide. Objective. To design peptide-based anti-polio vaccines exempt from potential cross-reactivity risks and possibly able to reduce rare potential adverse...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/541282 |
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| author | Darja Kanduc Candida Fasano Giovanni Capone Antonella Pesce Delfino Michele Calabrò Lorenzo Polimeno |
| author_facet | Darja Kanduc Candida Fasano Giovanni Capone Antonella Pesce Delfino Michele Calabrò Lorenzo Polimeno |
| author_sort | Darja Kanduc |
| collection | DOAJ |
| description | Background. Although rare, adverse events may associate with anti-poliovirus vaccination thus possibly hampering global polio eradication worldwide. Objective. To design peptide-based anti-polio vaccines exempt from potential cross-reactivity risks and possibly able to reduce rare potential adverse events such as the postvaccine paralytic poliomyelitis due to the tendency of the poliovirus genome to mutate. Methods. Proteins from poliovirus type 1, strain Mahoney, were analyzed for amino acid sequence identity to the human proteome at the pentapeptide level, searching for sequences that (1) have zero percent of identity to human proteins, (2) are potentially endowed with an immunologic potential, and (3) are highly conserved among poliovirus strains. Results. Sequence analyses produced a set of consensus epitopic peptides potentially able to generate specific anti-polio immune responses exempt from cross-reactivity with the human host. Conclusion. Peptide sequences unique to poliovirus proteins and conserved among polio strains might help formulate a specific and universal anti-polio vaccine able to react with multiple viral strains and exempt from the burden of possible cross-reactions with human proteins. As an additional advantage, using a peptide-based vaccine instead of current anti-polio DNA vaccines would eliminate the rare post-polio poliomyelitis cases and other disabling symptoms that may appear following vaccination. |
| format | Article |
| id | doaj-art-4d974cc175b64229b3e9affe56fa478f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-4d974cc175b64229b3e9affe56fa478f2025-02-03T06:42:22ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/541282541282Applying the Concept of Peptide Uniqueness to Anti-Polio VaccinationDarja Kanduc0Candida Fasano1Giovanni Capone2Antonella Pesce Delfino3Michele Calabrò4Lorenzo Polimeno5Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, 70126 Bari, ItalyDepartment of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, 70126 Bari, ItalyDepartment of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, 70126 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (DETO), University of Bari, 70124 Bari, ItalyBackground. Although rare, adverse events may associate with anti-poliovirus vaccination thus possibly hampering global polio eradication worldwide. Objective. To design peptide-based anti-polio vaccines exempt from potential cross-reactivity risks and possibly able to reduce rare potential adverse events such as the postvaccine paralytic poliomyelitis due to the tendency of the poliovirus genome to mutate. Methods. Proteins from poliovirus type 1, strain Mahoney, were analyzed for amino acid sequence identity to the human proteome at the pentapeptide level, searching for sequences that (1) have zero percent of identity to human proteins, (2) are potentially endowed with an immunologic potential, and (3) are highly conserved among poliovirus strains. Results. Sequence analyses produced a set of consensus epitopic peptides potentially able to generate specific anti-polio immune responses exempt from cross-reactivity with the human host. Conclusion. Peptide sequences unique to poliovirus proteins and conserved among polio strains might help formulate a specific and universal anti-polio vaccine able to react with multiple viral strains and exempt from the burden of possible cross-reactions with human proteins. As an additional advantage, using a peptide-based vaccine instead of current anti-polio DNA vaccines would eliminate the rare post-polio poliomyelitis cases and other disabling symptoms that may appear following vaccination.http://dx.doi.org/10.1155/2015/541282 |
| spellingShingle | Darja Kanduc Candida Fasano Giovanni Capone Antonella Pesce Delfino Michele Calabrò Lorenzo Polimeno Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination Journal of Immunology Research |
| title | Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination |
| title_full | Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination |
| title_fullStr | Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination |
| title_full_unstemmed | Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination |
| title_short | Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination |
| title_sort | applying the concept of peptide uniqueness to anti polio vaccination |
| url | http://dx.doi.org/10.1155/2015/541282 |
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