Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibility
Stress-induced psychiatric symptoms, such as increased anxiety, decreased sociality, and depression, differ considerably across individuals. The cognitive model of depression proposes that biased negative memory is a crucial determinant in the development of mental stress-induced disorders. Accumula...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Neuroscience Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168010222002139 |
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| author | Nahoko Kuga Takuya Sasaki |
| author_facet | Nahoko Kuga Takuya Sasaki |
| author_sort | Nahoko Kuga |
| collection | DOAJ |
| description | Stress-induced psychiatric symptoms, such as increased anxiety, decreased sociality, and depression, differ considerably across individuals. The cognitive model of depression proposes that biased negative memory is a crucial determinant in the development of mental stress-induced disorders. Accumulating evidence from both clinical and animal studies has demonstrated that such biased memory processing could be triggered by the hippocampus, a region well known to be involved in declarative memories. This review mainly describes how memory-related neurophysiological mechanisms in the hippocampus and their interactions with other related brain regions are involved in the regulation of stress susceptibility and discusses potential interventions to prevent and treat stress-related psychiatric symptoms. Further neurophysiological insights based on memory mechanisms are expected to devise personalized prevention and therapy to confer stress resilience. |
| format | Article |
| id | doaj-art-4d951fb1d48142d9b85d8f4a452effc2 |
| institution | Kabale University |
| issn | 0168-0102 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroscience Research |
| spelling | doaj-art-4d951fb1d48142d9b85d8f4a452effc22025-02-06T05:10:59ZengElsevierNeuroscience Research0168-01022025-02-0121139Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibilityNahoko Kuga0Takuya Sasaki1Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, JapanCorresponding author.; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, JapanStress-induced psychiatric symptoms, such as increased anxiety, decreased sociality, and depression, differ considerably across individuals. The cognitive model of depression proposes that biased negative memory is a crucial determinant in the development of mental stress-induced disorders. Accumulating evidence from both clinical and animal studies has demonstrated that such biased memory processing could be triggered by the hippocampus, a region well known to be involved in declarative memories. This review mainly describes how memory-related neurophysiological mechanisms in the hippocampus and their interactions with other related brain regions are involved in the regulation of stress susceptibility and discusses potential interventions to prevent and treat stress-related psychiatric symptoms. Further neurophysiological insights based on memory mechanisms are expected to devise personalized prevention and therapy to confer stress resilience.http://www.sciencedirect.com/science/article/pii/S0168010222002139StressResilienceMemoryHippocampusOscillation |
| spellingShingle | Nahoko Kuga Takuya Sasaki Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibility Neuroscience Research Stress Resilience Memory Hippocampus Oscillation |
| title | Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibility |
| title_full | Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibility |
| title_fullStr | Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibility |
| title_full_unstemmed | Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibility |
| title_short | Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibility |
| title_sort | memory related neurophysiological mechanisms in the hippocampus underlying stress susceptibility |
| topic | Stress Resilience Memory Hippocampus Oscillation |
| url | http://www.sciencedirect.com/science/article/pii/S0168010222002139 |
| work_keys_str_mv | AT nahokokuga memoryrelatedneurophysiologicalmechanismsinthehippocampusunderlyingstresssusceptibility AT takuyasasaki memoryrelatedneurophysiologicalmechanismsinthehippocampusunderlyingstresssusceptibility |