Biomarker urinary neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury in neonates
Aim To evaluate urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as a predictive biomarker for Acute Kidney Injury (AKI) in neonates undergoing gastrointestinal surgery.Materials & Methods A prospective cohort study included 45 neonates with gastrointestinal congenital malformations wh...
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Taylor & Francis Group
2025-12-01
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| Series: | Future Science OA |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20565623.2025.2463854 |
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| author | Altynay Sadykova Riza Boranbayeva Gulnara Tashenova Gulbanu Berdiyarova Aigul Tulebayeva Vladimir Zhovnir Ildar Fakhradiyev |
| author_facet | Altynay Sadykova Riza Boranbayeva Gulnara Tashenova Gulbanu Berdiyarova Aigul Tulebayeva Vladimir Zhovnir Ildar Fakhradiyev |
| author_sort | Altynay Sadykova |
| collection | DOAJ |
| description | Aim To evaluate urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as a predictive biomarker for Acute Kidney Injury (AKI) in neonates undergoing gastrointestinal surgery.Materials & Methods A prospective cohort study included 45 neonates with gastrointestinal congenital malformations who underwent abdominal surgery within the first 28 days of life at two pediatric centers in Almaty, Kazakhstan. AKI was diagnosed using modified neonatal KDIGO criteria, dividing neonates into AKI[+] and AKI[-] groups. uNGAL levels were measured pre-surgery and on postoperative days 1, 3, and 7. Statistical analysis, including ROC curve analysis, was performed using SPSS to evaluate uNGAL’s sensitivity and specificity as a biomarker.Results AKI was diagnosed in 42.2% of neonates. Pre-surgery uNGAL levels were significantly higher in the AKI group (184.4 ng/ml vs. 56.5 ng/ml). Post-surgery, uNGAL peaked at 493.9 ng/ml on day 1, with sensitivities of 89.5% and 94.7% on days 1 and 7. Specificity was highest on days 1 and 3 (96.2% and 100%). The mortality rate among AKI-affected neonates was 31.5%.Conclusion uNGAL is a sensitive and specific biomarker for early AKI detection in neonates post-gastrointestinal surgery, enabling timely interventions and potentially reducing mortality. |
| format | Article |
| id | doaj-art-4d934fce8b1a456584cac6a2d2f6d0b2 |
| institution | OA Journals |
| issn | 2056-5623 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-4d934fce8b1a456584cac6a2d2f6d0b22025-08-20T02:30:10ZengTaylor & Francis GroupFuture Science OA2056-56232025-12-0111110.1080/20565623.2025.2463854Biomarker urinary neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury in neonatesAltynay Sadykova0Riza Boranbayeva1Gulnara Tashenova2Gulbanu Berdiyarova3Aigul Tulebayeva4Vladimir Zhovnir5Ildar Fakhradiyev6Department of Medicine, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Republic of KazakhstanDepartment of Medicine, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Republic of KazakhstanDepartment of Medicine, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Republic of KazakhstanDepartment of Medicine, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Republic of KazakhstanDepartment of Medicine, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Republic of KazakhstanDepartment of Medicine, National specialized children’s hospital “Ohmatdyt” Ministry of Health of Ukraine, Kyiv, UkraineDepartment of Medicine, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Republic of KazakhstanAim To evaluate urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as a predictive biomarker for Acute Kidney Injury (AKI) in neonates undergoing gastrointestinal surgery.Materials & Methods A prospective cohort study included 45 neonates with gastrointestinal congenital malformations who underwent abdominal surgery within the first 28 days of life at two pediatric centers in Almaty, Kazakhstan. AKI was diagnosed using modified neonatal KDIGO criteria, dividing neonates into AKI[+] and AKI[-] groups. uNGAL levels were measured pre-surgery and on postoperative days 1, 3, and 7. Statistical analysis, including ROC curve analysis, was performed using SPSS to evaluate uNGAL’s sensitivity and specificity as a biomarker.Results AKI was diagnosed in 42.2% of neonates. Pre-surgery uNGAL levels were significantly higher in the AKI group (184.4 ng/ml vs. 56.5 ng/ml). Post-surgery, uNGAL peaked at 493.9 ng/ml on day 1, with sensitivities of 89.5% and 94.7% on days 1 and 7. Specificity was highest on days 1 and 3 (96.2% and 100%). The mortality rate among AKI-affected neonates was 31.5%.Conclusion uNGAL is a sensitive and specific biomarker for early AKI detection in neonates post-gastrointestinal surgery, enabling timely interventions and potentially reducing mortality.https://www.tandfonline.com/doi/10.1080/20565623.2025.2463854Neonatal AKIacute kidney injurypostoperativeneonateabdominal surgeryperioperative AKI |
| spellingShingle | Altynay Sadykova Riza Boranbayeva Gulnara Tashenova Gulbanu Berdiyarova Aigul Tulebayeva Vladimir Zhovnir Ildar Fakhradiyev Biomarker urinary neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury in neonates Future Science OA Neonatal AKI acute kidney injury postoperative neonate abdominal surgery perioperative AKI |
| title | Biomarker urinary neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury in neonates |
| title_full | Biomarker urinary neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury in neonates |
| title_fullStr | Biomarker urinary neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury in neonates |
| title_full_unstemmed | Biomarker urinary neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury in neonates |
| title_short | Biomarker urinary neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury in neonates |
| title_sort | biomarker urinary neutrophil gelatinase associated lipocalin as a predictor of acute kidney injury in neonates |
| topic | Neonatal AKI acute kidney injury postoperative neonate abdominal surgery perioperative AKI |
| url | https://www.tandfonline.com/doi/10.1080/20565623.2025.2463854 |
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