Spontaneous Retroperitoneal Hemorrhage in a Patient with Prolymphocytic Transformation of Chronic Lymphocytic Leukemia
Prolymphocytic transformation of chronic lymphocytic leukemia is a rare but recognized entity. We present the case of a 76-year-old gentleman with a previous diagnosis of chronic lymphocytic leukemia who presented with fatigue, fever, and a white blood cell count of 500 000 with prolymphocytes on pe...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/802376 |
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| author | Gwynivere A. Davies Alejandro Lazo-Langner Michael Shkrum Leonard Minuk |
| author_facet | Gwynivere A. Davies Alejandro Lazo-Langner Michael Shkrum Leonard Minuk |
| author_sort | Gwynivere A. Davies |
| collection | DOAJ |
| description | Prolymphocytic transformation of chronic lymphocytic leukemia is a rare but recognized entity. We present the case of a 76-year-old gentleman with a previous diagnosis of chronic lymphocytic leukemia who presented with fatigue, fever, and a white blood cell count of 500 000 with prolymphocytes on peripheral blood examination. Chlorambucil and dexamethasone were initiated. He developed progressive anemia during his admission with no clear cause on initial CT examination. Bilateral hip pain began several days later and he was unfortunately diagnosed with a large spontaneous retroperitoneal hemorrhage postmortem. This condition is rare and generally occurs in those receiving therapeutic anticoagulation or dialysis, with known bleeding disorders or vascular malformation, none of which were present in our patient. Pathology revealed marked leukemoid engorgement of the vessels of many organs with prolymphocytes. We discuss the potential etiologies and relationships between these critical diagnoses. |
| format | Article |
| id | doaj-art-4d930fdaa00c42f9977d11c6128039d5 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-4d930fdaa00c42f9977d11c6128039d52025-02-03T01:26:32ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/802376802376Spontaneous Retroperitoneal Hemorrhage in a Patient with Prolymphocytic Transformation of Chronic Lymphocytic LeukemiaGwynivere A. Davies0Alejandro Lazo-Langner1Michael Shkrum2Leonard Minuk3Department of Medicine, Western University, London, ON, CanadaDivision of Hematology, Department of Medicine, Western University, London Health Sciences Centre, Room E6-219, Victoria Hospital, 800 Commissioners Road East, P.O. Box 5010, London, ON, N6A 4G5, CanadaDepartment of Pathology, Western University, London, ON, CanadaDivision of Hematology, Department of Medicine, Western University, London Health Sciences Centre, Room E6-219, Victoria Hospital, 800 Commissioners Road East, P.O. Box 5010, London, ON, N6A 4G5, CanadaProlymphocytic transformation of chronic lymphocytic leukemia is a rare but recognized entity. We present the case of a 76-year-old gentleman with a previous diagnosis of chronic lymphocytic leukemia who presented with fatigue, fever, and a white blood cell count of 500 000 with prolymphocytes on peripheral blood examination. Chlorambucil and dexamethasone were initiated. He developed progressive anemia during his admission with no clear cause on initial CT examination. Bilateral hip pain began several days later and he was unfortunately diagnosed with a large spontaneous retroperitoneal hemorrhage postmortem. This condition is rare and generally occurs in those receiving therapeutic anticoagulation or dialysis, with known bleeding disorders or vascular malformation, none of which were present in our patient. Pathology revealed marked leukemoid engorgement of the vessels of many organs with prolymphocytes. We discuss the potential etiologies and relationships between these critical diagnoses.http://dx.doi.org/10.1155/2013/802376 |
| spellingShingle | Gwynivere A. Davies Alejandro Lazo-Langner Michael Shkrum Leonard Minuk Spontaneous Retroperitoneal Hemorrhage in a Patient with Prolymphocytic Transformation of Chronic Lymphocytic Leukemia Case Reports in Hematology |
| title | Spontaneous Retroperitoneal Hemorrhage in a Patient with Prolymphocytic Transformation of Chronic Lymphocytic Leukemia |
| title_full | Spontaneous Retroperitoneal Hemorrhage in a Patient with Prolymphocytic Transformation of Chronic Lymphocytic Leukemia |
| title_fullStr | Spontaneous Retroperitoneal Hemorrhage in a Patient with Prolymphocytic Transformation of Chronic Lymphocytic Leukemia |
| title_full_unstemmed | Spontaneous Retroperitoneal Hemorrhage in a Patient with Prolymphocytic Transformation of Chronic Lymphocytic Leukemia |
| title_short | Spontaneous Retroperitoneal Hemorrhage in a Patient with Prolymphocytic Transformation of Chronic Lymphocytic Leukemia |
| title_sort | spontaneous retroperitoneal hemorrhage in a patient with prolymphocytic transformation of chronic lymphocytic leukemia |
| url | http://dx.doi.org/10.1155/2013/802376 |
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