Investigation of corneal hydration and the impact of cross-linking therapy on water retention using Brillouin spectroscopy, Raman spectroscopy and polarization-sensitive optical coherence tomography

Investigation of corneal hydration and the impact of cross-linking therapy on water retention using Brillouin spectroscopy, Raman spectroscopy and polarization-sensitive optical coherence tomography

Recently, Brillouin spectroscopy has been proposed as a promising non-invasive tool to evaluate corneal biomechanics, e.g., during corneal cross-linking (CXL) treatment. However, the impact of corneal hydration on the Brillouin shift hampers straightforward interpretation of the measurements, especi...

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Bibliographic Details
Main Authors: Jan Rix, Svea Steuer, Jonas Golde, Fadi Husein, Felix Lochmann, Steven Melcher, Gerald Steiner, Roberta Galli, Julia Walther, Frederik Raiskup, Ramin Khoramnia, Robert Herber
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
cornea
corneal cross-linking
Brillouin
Raman
PS-OCT
hydration
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1576809/full
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