A Puzzling Case of Rapidly Progressive Global CNS Deterioration From Intravascular Large-Cell Lymphoma
Intravascular large-cell lymphoma is a rare, aggressive subtype of B-cell lymphoma leading to microvascular organ dysfunction. It often presents nonspecifically and is difficult to diagnose, with a rapidly progressive course. It classically presents with “B” symptoms, although any organ system can b...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2023-01-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0356 |
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| _version_ | 1849698999243636736 |
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| author | Chloe Weidenbaum Akanksha Kushwah Henry Edwards Rachel Ward Joy Underwood Dyveke Pratt |
| author_facet | Chloe Weidenbaum Akanksha Kushwah Henry Edwards Rachel Ward Joy Underwood Dyveke Pratt |
| author_sort | Chloe Weidenbaum |
| collection | DOAJ |
| description | Intravascular large-cell lymphoma is a rare, aggressive subtype of B-cell lymphoma leading to microvascular organ dysfunction. It often presents nonspecifically and is difficult to diagnose, with a rapidly progressive course. It classically presents with “B” symptoms, although any organ system can be affected. Neurologic symptoms vary but can involve rapid neurologic deterioration. It lacks association with a primary tumor or malignant cells in the blood or bone marrow, so diagnosis is difficult, made only by biopsy of affected tissues. Because of its rarity and often aggressive course, increased clinician familiarity is key to facilitating early diagnosis and proper management. |
| format | Article |
| id | doaj-art-4d76a9e7a447415c94347b498282467e |
| institution | DOAJ |
| issn | 2767-7664 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-4d76a9e7a447415c94347b498282467e2025-08-20T03:18:45ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642023-01-012110.7326/aimcc.2022.0356A Puzzling Case of Rapidly Progressive Global CNS Deterioration From Intravascular Large-Cell LymphomaChloe Weidenbaum0Akanksha Kushwah1Henry Edwards2Rachel Ward3Joy Underwood4Dyveke Pratt51Department of Internal Medicine, University of Tennessee Health Science Center – Nashville, Nashville, Tennessee1Department of Internal Medicine, University of Tennessee Health Science Center – Nashville, Nashville, Tennessee2Ascension Saint Thomas Hospitals, Nashville, Tennessee1Department of Internal Medicine, University of Tennessee Health Science Center – Nashville, Nashville, Tennessee1Department of Internal Medicine, University of Tennessee Health Science Center – Nashville, Nashville, Tennessee2Ascension Saint Thomas Hospitals, Nashville, TennesseeIntravascular large-cell lymphoma is a rare, aggressive subtype of B-cell lymphoma leading to microvascular organ dysfunction. It often presents nonspecifically and is difficult to diagnose, with a rapidly progressive course. It classically presents with “B” symptoms, although any organ system can be affected. Neurologic symptoms vary but can involve rapid neurologic deterioration. It lacks association with a primary tumor or malignant cells in the blood or bone marrow, so diagnosis is difficult, made only by biopsy of affected tissues. Because of its rarity and often aggressive course, increased clinician familiarity is key to facilitating early diagnosis and proper management.https://www.acpjournals.org/doi/10.7326/aimcc.2022.0356 |
| spellingShingle | Chloe Weidenbaum Akanksha Kushwah Henry Edwards Rachel Ward Joy Underwood Dyveke Pratt A Puzzling Case of Rapidly Progressive Global CNS Deterioration From Intravascular Large-Cell Lymphoma Annals of Internal Medicine: Clinical Cases |
| title | A Puzzling Case of Rapidly Progressive Global CNS Deterioration From Intravascular Large-Cell Lymphoma |
| title_full | A Puzzling Case of Rapidly Progressive Global CNS Deterioration From Intravascular Large-Cell Lymphoma |
| title_fullStr | A Puzzling Case of Rapidly Progressive Global CNS Deterioration From Intravascular Large-Cell Lymphoma |
| title_full_unstemmed | A Puzzling Case of Rapidly Progressive Global CNS Deterioration From Intravascular Large-Cell Lymphoma |
| title_short | A Puzzling Case of Rapidly Progressive Global CNS Deterioration From Intravascular Large-Cell Lymphoma |
| title_sort | puzzling case of rapidly progressive global cns deterioration from intravascular large cell lymphoma |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0356 |
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