Male mouse skeletal muscle lacking HuR shows enhanced glucose disposal at a young age

Male mouse skeletal muscle lacking HuR shows enhanced glucose disposal at a young age

IntroductionMetabolic flexibility is the ability of a system to switch between metabolic substrates. Human and murine skeletal muscle tissues and cells with decreased activity of the regulatory RNA-binding protein, human antigen R (HuR), have decreased capacity for fat oxidation, and thus decreased...

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Main Authors: Robert C. Noland, Sujoy Ghosh, Carlos J. Crisanto, Antonio Aleman, McKenna K. Chaney, Maitri K. Chauhan, Layla G. Loftis, Ally C. Goad, Christin F. Rickman, Samuel E. Velasquez, Jaycob D. Warfel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Physiology
Subjects:
human antigen R
metabolic flexibility
RNA-binding proteins
fat oxidation
carbohydrate oxidation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1468369/full
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