A cohort of mRNAs undergo high-stoichiometry NSUN6-mediated site-specific m5C modification

A cohort of mRNAs undergo high-stoichiometry NSUN6-mediated site-specific m5C modification

Abstract mRNA modifications are vital in regulating cellular processes. Beyond N6-methyladenosine (m6A), most other internal mRNA modifications lack dedicated catalytic machinery and are typically introduced by tRNA-modifying enzymes. The distribution and stoichiometry of these modifications on mRNA...

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Main Authors: Yuan-Yuan Zhang, Cai-Tao Li, You-Jia Zhou, Hao Li, Jing Li, Qing-Ping Xiong, Wei Zhou, Wenze Huang, Qiangfeng Cliff Zhang, Yangfei Xiang, En-Duo Wang, Beisi Xu, Ru-Juan Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60873-4
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