Astragaloside IV- loaded biomimetic nanoparticles target IκBα to regulate neutrophil extracellular trap formation for sepsis therapy

Astragaloside IV- loaded biomimetic nanoparticles target IκBα to regulate neutrophil extracellular trap formation for sepsis therapy

Abstract This study explored the novel mechanism of Astragaloside IV (As) in treating sepsis and its application through a biomimetic nano-delivery system (As@ZM). Sepsis, a condition of organ dysfunction caused by an abnormal host response to infection, poses a significant threat to global health d...

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Bibliographic Details
Main Authors: Shujuan Wu, Mengqi Zhou, Huimin Zhou, Lu Han, Huifan Liu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Nanobiotechnology
Subjects:
Sepsis
Astragaloside IV
Neutrophil extracellular traps
NF-κB
Biomimetic nanoparticle
Online Access:https://doi.org/10.1186/s12951-025-03260-x
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