Genetic causality between insomnia and specific orthopedic conditions: Insights from a two-sample Mendelian randomization study
Objective: To investigate the genetic causality for the insomnia and common orthopedic diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), osteoporosis (OP), and gout (GT). Methods: The genome-wide association study (GWAS) summary data on insomnia were obtained from a published...
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Elsevier
2025-02-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556525000105 |
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| author | Mingyi Yang Jiale Xie Yani Su Ke Xu Pengfei Wen Xianjie Wan Hui Yu Zhi Yang Lin Liu Peng Xu |
| author_facet | Mingyi Yang Jiale Xie Yani Su Ke Xu Pengfei Wen Xianjie Wan Hui Yu Zhi Yang Lin Liu Peng Xu |
| author_sort | Mingyi Yang |
| collection | DOAJ |
| description | Objective: To investigate the genetic causality for the insomnia and common orthopedic diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), osteoporosis (OP), and gout (GT). Methods: The genome-wide association study (GWAS) summary data on insomnia were obtained from a published study, while the GWAS summary data on RA, AS, OP, and GT were sourced from the FinnGen consortium. We utilized the TwoSampleMR package of the R software (version 4.1.2) to conduct a two-sample Mendelian randomization (MR) analysis. Our primary method of analysis was the random-effects inverse variance weighted (IVW) approach. Subsequently, we conducted a series of sensitivity analyses for the MR analysis. Results: The MR analysis revealed a positive genetic causal relationship between insomnia and RA (P = 0.016, odds ratio [OR] 95 % confidence interval [CI] = 1.112 [1.020–1.212]). However, no significant genetic causal relationship was observed between insomnia and AS (P = 0.194, OR 95 % CI = 1.121 [0.944–1.331]), OP (P = 0.788, OR 95 % CI = 1.016 [0.904–1.142]), and GT (P = 0.757, OR 95 % CI = 1.018 [0.912–1.136]). The MR analysis did not exhibit heterogeneity, horizontal pleiotropy, outlier effects, or dependence on a single SNP, and demonstrated normal distribution, which guaranteed the robustness of the results. Conclusion: The results of this study suggest that insomnia may be a significant risk factor for RA, and controlling insomnia may represent a promising strategy for preventing RA. While insomnia was not observed to be associated with AS, OP, and GT at the genetic level, other levels of association cannot be excluded. |
| format | Article |
| id | doaj-art-4d6aeab72bad4e2788d76278f539c46b |
| institution | Kabale University |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-4d6aeab72bad4e2788d76278f539c46b2025-01-31T05:10:08ZengElsevierExperimental Gerontology1873-68152025-02-01200112682Genetic causality between insomnia and specific orthopedic conditions: Insights from a two-sample Mendelian randomization studyMingyi Yang0Jiale Xie1Yani Su2Ke Xu3Pengfei Wen4Xianjie Wan5Hui Yu6Zhi Yang7Lin Liu8Peng Xu9Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, China; Xi'an Key Laboratory of Pathogenesis and Precision Treatment of Arthritis, Xi'an, Shaanxi 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, China; Xi'an Key Laboratory of Pathogenesis and Precision Treatment of Arthritis, Xi'an, Shaanxi 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, China; Xi'an Key Laboratory of Pathogenesis and Precision Treatment of Arthritis, Xi'an, Shaanxi 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, China; Xi'an Key Laboratory of Pathogenesis and Precision Treatment of Arthritis, Xi'an, Shaanxi 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, China; Xi'an Key Laboratory of Pathogenesis and Precision Treatment of Arthritis, Xi'an, Shaanxi 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, China; Corresponding author.Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, China; Xi'an Key Laboratory of Pathogenesis and Precision Treatment of Arthritis, Xi'an, Shaanxi 710054, China; Correspondence to: P. Xu, Xi'an Key Laboratory of Pathogenesis and Precision Treatment of Arthritis, Xi'an, Shaanxi 710054, China.Objective: To investigate the genetic causality for the insomnia and common orthopedic diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), osteoporosis (OP), and gout (GT). Methods: The genome-wide association study (GWAS) summary data on insomnia were obtained from a published study, while the GWAS summary data on RA, AS, OP, and GT were sourced from the FinnGen consortium. We utilized the TwoSampleMR package of the R software (version 4.1.2) to conduct a two-sample Mendelian randomization (MR) analysis. Our primary method of analysis was the random-effects inverse variance weighted (IVW) approach. Subsequently, we conducted a series of sensitivity analyses for the MR analysis. Results: The MR analysis revealed a positive genetic causal relationship between insomnia and RA (P = 0.016, odds ratio [OR] 95 % confidence interval [CI] = 1.112 [1.020–1.212]). However, no significant genetic causal relationship was observed between insomnia and AS (P = 0.194, OR 95 % CI = 1.121 [0.944–1.331]), OP (P = 0.788, OR 95 % CI = 1.016 [0.904–1.142]), and GT (P = 0.757, OR 95 % CI = 1.018 [0.912–1.136]). The MR analysis did not exhibit heterogeneity, horizontal pleiotropy, outlier effects, or dependence on a single SNP, and demonstrated normal distribution, which guaranteed the robustness of the results. Conclusion: The results of this study suggest that insomnia may be a significant risk factor for RA, and controlling insomnia may represent a promising strategy for preventing RA. While insomnia was not observed to be associated with AS, OP, and GT at the genetic level, other levels of association cannot be excluded.http://www.sciencedirect.com/science/article/pii/S0531556525000105Insomnia, rheumatoid arthritisAnkylosing spondylitisOsteoporosisGoutGenetic |
| spellingShingle | Mingyi Yang Jiale Xie Yani Su Ke Xu Pengfei Wen Xianjie Wan Hui Yu Zhi Yang Lin Liu Peng Xu Genetic causality between insomnia and specific orthopedic conditions: Insights from a two-sample Mendelian randomization study Experimental Gerontology Insomnia, rheumatoid arthritis Ankylosing spondylitis Osteoporosis Gout Genetic |
| title | Genetic causality between insomnia and specific orthopedic conditions: Insights from a two-sample Mendelian randomization study |
| title_full | Genetic causality between insomnia and specific orthopedic conditions: Insights from a two-sample Mendelian randomization study |
| title_fullStr | Genetic causality between insomnia and specific orthopedic conditions: Insights from a two-sample Mendelian randomization study |
| title_full_unstemmed | Genetic causality between insomnia and specific orthopedic conditions: Insights from a two-sample Mendelian randomization study |
| title_short | Genetic causality between insomnia and specific orthopedic conditions: Insights from a two-sample Mendelian randomization study |
| title_sort | genetic causality between insomnia and specific orthopedic conditions insights from a two sample mendelian randomization study |
| topic | Insomnia, rheumatoid arthritis Ankylosing spondylitis Osteoporosis Gout Genetic |
| url | http://www.sciencedirect.com/science/article/pii/S0531556525000105 |
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