Copper Imparts a New Therapeutic Property to Resveratrol by Generating ROS to Deactivate Cell-Free Chromatin
Resveratrol, a bioactive phytoalexin, has been extensively studied as a pharmaceutical and nutraceutical candidate for the treatment of various diseases. Although its therapeutic effects have been largely attributed to its anti-oxidant properties, its underlying mechanisms and dose dependency are no...
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MDPI AG
2025-01-01
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| author | Salooni Khanvilkar Indraneel Mittra |
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| description | Resveratrol, a bioactive phytoalexin, has been extensively studied as a pharmaceutical and nutraceutical candidate for the treatment of various diseases. Although its therapeutic effects have been largely attributed to its anti-oxidant properties, its underlying mechanisms and dose dependency are not well understood. Recent studies have shown that cell-free chromatin particles (cfChPs), which are released daily from billions of dying cells, can enter circulation and be internalized by healthy cells, wherein they trigger various damaging effects, including double-strand DNA breaks. Notably, deactivating cfChPs using a mixture of resveratrol and copper can neutralize their harmful effects. The addition of copper imparts a novel therapeutic property to resveratrol viz. the generation of reactive oxygen species (ROS), which are capable of deactivating cfChPs without damaging the genomic DNA. This perspective article discusses how the deactivation of cfChPs via the ROS generated by combining resveratrol with copper can have multiple therapeutic effects. Exploiting the damaging effects of ROS to deactivate cfChPs and ameliorate disease conditions may be a viable therapeutic approach. |
| format | Article |
| id | doaj-art-4d675d9d075540afb24909fbceca1217 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-4d675d9d075540afb24909fbceca12172025-01-24T13:45:31ZengMDPI AGPharmaceuticals1424-82472025-01-0118113210.3390/ph18010132Copper Imparts a New Therapeutic Property to Resveratrol by Generating ROS to Deactivate Cell-Free ChromatinSalooni Khanvilkar0Indraneel Mittra1Translational Research Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, IndiaTranslational Research Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, IndiaResveratrol, a bioactive phytoalexin, has been extensively studied as a pharmaceutical and nutraceutical candidate for the treatment of various diseases. Although its therapeutic effects have been largely attributed to its anti-oxidant properties, its underlying mechanisms and dose dependency are not well understood. Recent studies have shown that cell-free chromatin particles (cfChPs), which are released daily from billions of dying cells, can enter circulation and be internalized by healthy cells, wherein they trigger various damaging effects, including double-strand DNA breaks. Notably, deactivating cfChPs using a mixture of resveratrol and copper can neutralize their harmful effects. The addition of copper imparts a novel therapeutic property to resveratrol viz. the generation of reactive oxygen species (ROS), which are capable of deactivating cfChPs without damaging the genomic DNA. This perspective article discusses how the deactivation of cfChPs via the ROS generated by combining resveratrol with copper can have multiple therapeutic effects. Exploiting the damaging effects of ROS to deactivate cfChPs and ameliorate disease conditions may be a viable therapeutic approach.https://www.mdpi.com/1424-8247/18/1/132resveratrolcoppercell-free chromatin particlesreactive oxygen speciestherapeuticsnutraceuticals |
| spellingShingle | Salooni Khanvilkar Indraneel Mittra Copper Imparts a New Therapeutic Property to Resveratrol by Generating ROS to Deactivate Cell-Free Chromatin Pharmaceuticals resveratrol copper cell-free chromatin particles reactive oxygen species therapeutics nutraceuticals |
| title | Copper Imparts a New Therapeutic Property to Resveratrol by Generating ROS to Deactivate Cell-Free Chromatin |
| title_full | Copper Imparts a New Therapeutic Property to Resveratrol by Generating ROS to Deactivate Cell-Free Chromatin |
| title_fullStr | Copper Imparts a New Therapeutic Property to Resveratrol by Generating ROS to Deactivate Cell-Free Chromatin |
| title_full_unstemmed | Copper Imparts a New Therapeutic Property to Resveratrol by Generating ROS to Deactivate Cell-Free Chromatin |
| title_short | Copper Imparts a New Therapeutic Property to Resveratrol by Generating ROS to Deactivate Cell-Free Chromatin |
| title_sort | copper imparts a new therapeutic property to resveratrol by generating ros to deactivate cell free chromatin |
| topic | resveratrol copper cell-free chromatin particles reactive oxygen species therapeutics nutraceuticals |
| url | https://www.mdpi.com/1424-8247/18/1/132 |
| work_keys_str_mv | AT saloonikhanvilkar copperimpartsanewtherapeuticpropertytoresveratrolbygeneratingrostodeactivatecellfreechromatin AT indraneelmittra copperimpartsanewtherapeuticpropertytoresveratrolbygeneratingrostodeactivatecellfreechromatin |