Interleukin-1β in circulating mononuclear cells predicts steatotic liver disease improvement after weight loss in subjects with obesity and prediabetes or type 2 diabetes

Interleukin-1β in circulating mononuclear cells predicts steatotic liver disease improvement after weight loss in subjects with obesity and prediabetes or type 2 diabetes

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cardiovascular risk (CV) factor. Interleukin-1β (IL-1β), a cytokine involved in the pathogenesis of obesity-associated inflammation and type 2 diabetes (T2D), promotes hepatic steatosis. The Canakinumab A...

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Main Authors: Paola Giustina Simeone, Sarah Costantino, Rossella Liani, Romina Tripaldi, Augusto Di Castelnuovo, Armando Tartaro, Alessandro Mengozzi, Francesco Cosentino, Francesco Cipollone, Agostino Consoli, Francesco Paneni, Francesca Santilli
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cardiovascular Diabetology
Subjects:
Interleukin-1β
Obesity
MASLD
Liver disease
Prediabetes
Type 2 diabetes
Online Access:https://doi.org/10.1186/s12933-025-02706-8
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