HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection
Increased life expectancy and the need for long-term antiretroviral therapy have brought new challenges to the clinical management of HIV-infected individuals. The prevalence of osteoporosis and fractures is increased in HIV-infected patients; thus optimal strategies for risk management and treatmen...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2013/571418 |
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| _version_ | 1849406544501800960 |
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| author | Fabiola E. Del Carpio-Cano Raul A. DeLa Cadena Bassel E. Sawaya |
| author_facet | Fabiola E. Del Carpio-Cano Raul A. DeLa Cadena Bassel E. Sawaya |
| author_sort | Fabiola E. Del Carpio-Cano |
| collection | DOAJ |
| description | Increased life expectancy and the need for long-term antiretroviral therapy have brought new challenges to the clinical management of HIV-infected individuals. The prevalence of osteoporosis and fractures is increased in HIV-infected patients; thus optimal strategies for risk management and treatment in this group of patients need to be defined. Prevention of bone loss is an important component of HIV care as the HIV population grows older. Understanding the mechanisms by which HIV infection affects bone biology leading to osteoporosis is crucial to delineate potential adjuvant treatments. This review focuses on HIV-induced osteoporosis within the context of microRNAs (miRNAs) by reviewing first basic concepts of bone biology as well as current knowledge of the role of miRNAs in bone development. Evidence that HIV-associated osteoporosis is in part independent of therapies employed to treat HIV (HAART) is supported by cross-sectional and longitudinal studies and is the focus of this review. |
| format | Article |
| id | doaj-art-4d566ddea82849d89ba0c78c2aaa1755 |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-4d566ddea82849d89ba0c78c2aaa17552025-08-20T03:36:21ZengWileyJournal of Osteoporosis2090-80592042-00642013-01-01201310.1155/2013/571418571418HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV InfectionFabiola E. Del Carpio-Cano0Raul A. DeLa Cadena1Bassel E. Sawaya2Department of Physiology, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USADepartment of Physiology, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USADepartment of Physiology, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USAIncreased life expectancy and the need for long-term antiretroviral therapy have brought new challenges to the clinical management of HIV-infected individuals. The prevalence of osteoporosis and fractures is increased in HIV-infected patients; thus optimal strategies for risk management and treatment in this group of patients need to be defined. Prevention of bone loss is an important component of HIV care as the HIV population grows older. Understanding the mechanisms by which HIV infection affects bone biology leading to osteoporosis is crucial to delineate potential adjuvant treatments. This review focuses on HIV-induced osteoporosis within the context of microRNAs (miRNAs) by reviewing first basic concepts of bone biology as well as current knowledge of the role of miRNAs in bone development. Evidence that HIV-associated osteoporosis is in part independent of therapies employed to treat HIV (HAART) is supported by cross-sectional and longitudinal studies and is the focus of this review.http://dx.doi.org/10.1155/2013/571418 |
| spellingShingle | Fabiola E. Del Carpio-Cano Raul A. DeLa Cadena Bassel E. Sawaya HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection Journal of Osteoporosis |
| title | HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection |
| title_full | HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection |
| title_fullStr | HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection |
| title_full_unstemmed | HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection |
| title_short | HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection |
| title_sort | hiv and bone disease a perspective of the role of micrornas in bone biology upon hiv infection |
| url | http://dx.doi.org/10.1155/2013/571418 |
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