ANTIBODIES TO ESTRADIOL, PROGESTERONE, AND BENZO[A]PYRENE DETERMINE RISK OF PREMATURE RUPTURE OF MEMBRANES AT 22<sup>+0</sup> -36<sup>+6</sup> WEEKS
Aim. To determine the role of antibodies to estradiol (anti-Es), progesterone (anti-Pg), and benzo[a]pyrene (anti-Bp) in premature rupture of membranes (PROM). Materials and Methods. We recruited 68 women with PROM at 22+0-36+6 weeks and 81 women with a healthy pregnancy, with the further collection...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Kemerovo State Medical University
2017-09-01
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| Series: | Фундаментальная и клиническая медицина |
| Subjects: | |
| Online Access: | https://fcm.kemsmu.ru/jour/article/view/58 |
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| Summary: | Aim. To determine the role of antibodies to estradiol (anti-Es), progesterone (anti-Pg), and benzo[a]pyrene (anti-Bp) in premature rupture of membranes (PROM). Materials and Methods. We recruited 68 women with PROM at 22+0-36+6 weeks and 81 women with a healthy pregnancy, with the further collection of venous blood at 22+0-36+6 weeks following measurement of anti-Es, anti-Pg, and anti-Bp IgA and IgG using enzyme-linked immunosorbent assay. Results. We detected the elevated levels of anti-Es, anti-Pg, and anti-Bp as well as increased IgA Bp/Pg, IgA Es/Pg, and IgG Bp/Pg ratios in women with PROM in 22+0-36+6 weeks compared to those without. Conclusions. Measurement of antibodies to estradiol, progesterone, and benzo[a]pyrene may be useful to predict PROM. |
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| ISSN: | 2500-0764 2542-0941 |