Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment
Summary: Recent advancements in sonodynamic therapy (SDT) for cancer treatment have highlighted the potential of enhancing reactive oxygen species (ROS) generation and improving therapeutic outcomes. This study introduces zinc oxide (ZnO) nanorods (NRs) in situ loaded with silver nanoparticles (ZnO@...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422500118X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823859392025460736 |
|---|---|
| author | Yichao Tao Wenbin Zhuang Wensi Fan Longxiang Zhou Lihong Fan Huanlong Qin Yefei Zhu |
| author_facet | Yichao Tao Wenbin Zhuang Wensi Fan Longxiang Zhou Lihong Fan Huanlong Qin Yefei Zhu |
| author_sort | Yichao Tao |
| collection | DOAJ |
| description | Summary: Recent advancements in sonodynamic therapy (SDT) for cancer treatment have highlighted the potential of enhancing reactive oxygen species (ROS) generation and improving therapeutic outcomes. This study introduces zinc oxide (ZnO) nanorods (NRs) in situ loaded with silver nanoparticles (ZnO@Ag NRs), designed to optimize ROS production under ultrasound irradiation and offer significant advantages in tumor specificity and biosafety. The transmission electron microscopy and elemental mapping confirmed the consistent size and monodispersed Ag nanoparticle for ZnO@Ag NR. Sonodynamic properties showed that ZnO@Ag NRs produce higher singlet oxygen and hydroxyl radicals under ultrasound. In vitro studies demonstrated excellent biocompatibility and enhanced cell-killing effects of ZnO@Ag NRs on CT-26 cells, while in vivo results confirmed its superior anti-tumor efficacy and biosafety. Furthermore, the ZnO@Ag NRs’ antibacterial properties were also confirmed, suggesting additional benefits in treating cancers associated with bacterial infections. Collectively, these findings establish ZnO@Ag NRs as a potent and safe agent for ultrasound-driven cancer therapy. |
| format | Article |
| id | doaj-art-4d4c5a3609f44d1396fa0277f1aa52d6 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-4d4c5a3609f44d1396fa0277f1aa52d62025-02-11T04:35:20ZengElsevieriScience2589-00422025-02-01282111858Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatmentYichao Tao0Wenbin Zhuang1Wensi Fan2Longxiang Zhou3Lihong Fan4Huanlong Qin5Yefei Zhu6School of Medicine, Nantong University, Nantong 226001, China; Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Zhangjiagang Hospital of Traditional Chinese Medicine, Suzhou 215600, ChinaSchool of Medicine, Nantong University, Nantong 226001, China; Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaShanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of General Surgery, Jinshan Central Hospital Affiliated to Shanghai University of Medicine & Health Sciences, No.147, Jiankang Road, Shanghai 201599, ChinaSchool of Medicine, Nantong University, Nantong 226001, China; Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Corresponding authorSchool of Medicine, Nantong University, Nantong 226001, China; Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China; Corresponding authorDepartment of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225001, China; Corresponding authorSummary: Recent advancements in sonodynamic therapy (SDT) for cancer treatment have highlighted the potential of enhancing reactive oxygen species (ROS) generation and improving therapeutic outcomes. This study introduces zinc oxide (ZnO) nanorods (NRs) in situ loaded with silver nanoparticles (ZnO@Ag NRs), designed to optimize ROS production under ultrasound irradiation and offer significant advantages in tumor specificity and biosafety. The transmission electron microscopy and elemental mapping confirmed the consistent size and monodispersed Ag nanoparticle for ZnO@Ag NR. Sonodynamic properties showed that ZnO@Ag NRs produce higher singlet oxygen and hydroxyl radicals under ultrasound. In vitro studies demonstrated excellent biocompatibility and enhanced cell-killing effects of ZnO@Ag NRs on CT-26 cells, while in vivo results confirmed its superior anti-tumor efficacy and biosafety. Furthermore, the ZnO@Ag NRs’ antibacterial properties were also confirmed, suggesting additional benefits in treating cancers associated with bacterial infections. Collectively, these findings establish ZnO@Ag NRs as a potent and safe agent for ultrasound-driven cancer therapy.http://www.sciencedirect.com/science/article/pii/S258900422500118XTherapeuticsCancerMaterials scienceNanomaterials |
| spellingShingle | Yichao Tao Wenbin Zhuang Wensi Fan Longxiang Zhou Lihong Fan Huanlong Qin Yefei Zhu Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment iScience Therapeutics Cancer Materials science Nanomaterials |
| title | Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment |
| title_full | Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment |
| title_fullStr | Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment |
| title_full_unstemmed | Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment |
| title_short | Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment |
| title_sort | dual functional silver nanoparticle enhanced zno nanorods for improved reactive oxygen species generation and cancer treatment |
| topic | Therapeutics Cancer Materials science Nanomaterials |
| url | http://www.sciencedirect.com/science/article/pii/S258900422500118X |
| work_keys_str_mv | AT yichaotao dualfunctionalsilvernanoparticleenhancedznonanorodsforimprovedreactiveoxygenspeciesgenerationandcancertreatment AT wenbinzhuang dualfunctionalsilvernanoparticleenhancedznonanorodsforimprovedreactiveoxygenspeciesgenerationandcancertreatment AT wensifan dualfunctionalsilvernanoparticleenhancedznonanorodsforimprovedreactiveoxygenspeciesgenerationandcancertreatment AT longxiangzhou dualfunctionalsilvernanoparticleenhancedznonanorodsforimprovedreactiveoxygenspeciesgenerationandcancertreatment AT lihongfan dualfunctionalsilvernanoparticleenhancedznonanorodsforimprovedreactiveoxygenspeciesgenerationandcancertreatment AT huanlongqin dualfunctionalsilvernanoparticleenhancedznonanorodsforimprovedreactiveoxygenspeciesgenerationandcancertreatment AT yefeizhu dualfunctionalsilvernanoparticleenhancedznonanorodsforimprovedreactiveoxygenspeciesgenerationandcancertreatment |