Complete reference genome and pangenome improve genome-wide detection and interpretation of DNA methylation using sequencing and array data

Complete reference genome and pangenome improve genome-wide detection and interpretation of DNA methylation using sequencing and array data

Summary: The complete telomere-to-telomere human genome assembly (T2T-CHM13) and the draft human pangenome reference provide unique opportunities to refine DNA methylation (DNAm) studies. Here, we find that T2T-CHM13 calls 7.4% more CpGs genome wide compared to GRCh38 across four widely used short-r...

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Bibliographic Details
Main Authors: Zheng Dong, Joanne Whitehead, Maggie Fu, Julia L. MacIsaac, David H. Rehkopf, Luis Rosero-Bixby, Michael S. Kobor, Keegan Korthauer
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
Subjects:
CP: Genomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005261
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