Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder
BackgroundPrevious studies have demonstrated abnormal static intrahemispheric and interhemispheric functional connectivity between different brain regions in patients with alcohol use disorder (AUD). However, brain activity is highly dynamic.MethodsTo address this, we analyzed the dynamic changes in...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1531905/full |
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| author | Bohui Mei Yarui Wei Longyao Ma Qiuying Tao Jinghan Dang Jieping Sun Mengzhe Zhang Yong Zhang Jingliang Cheng |
| author_facet | Bohui Mei Yarui Wei Longyao Ma Qiuying Tao Jinghan Dang Jieping Sun Mengzhe Zhang Yong Zhang Jingliang Cheng |
| author_sort | Bohui Mei |
| collection | DOAJ |
| description | BackgroundPrevious studies have demonstrated abnormal static intrahemispheric and interhemispheric functional connectivity between different brain regions in patients with alcohol use disorder (AUD). However, brain activity is highly dynamic.MethodsTo address this, we analyzed the dynamic changes in intrahemispheric and interhemispheric connectivity patterns from 55 AUD patients and 32 healthy controls. The whole-brain functional connectivity was decomposed into ipsilateral and contralateral components, and the voxel-wise intrahemispheric and interhemispheric dynamic functional connectivity density (dFCD) was calculated using a sliding window analysis. At the same time, the relationship between dFCD values in abnormal brain regions and clinical variables was conducted.ResultsOur findings revealed that, compared to the HCs, AUD patients exhibited abnormal global, interhemispheric and intrahemispheric dFCD in the caudate, insula, parietal lobe, and occipital lobe. Furthermore, the dFCD values of these abnormal brain regions correlated with the average alcohol consumption and the severity of alcohol addiction in the AUD group.ConclusionsThe results indicate that brain regions associated with the salience network, default mode network, and visual network exhibited intrahemispheric and interhemispheric abnormal functional connectivity. This study underscores that dynamic metrics can provide overlapping or complementary information alongside static metrics, contributing to a more comprehensive understanding of neural activity in AUD. |
| format | Article |
| id | doaj-art-4d43553e6ca24cc38da9f362eed7a174 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-4d43553e6ca24cc38da9f362eed7a1742025-08-20T03:24:44ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-06-011610.3389/fpsyt.2025.15319051531905Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorderBohui MeiYarui WeiLongyao MaQiuying TaoJinghan DangJieping SunMengzhe ZhangYong ZhangJingliang ChengBackgroundPrevious studies have demonstrated abnormal static intrahemispheric and interhemispheric functional connectivity between different brain regions in patients with alcohol use disorder (AUD). However, brain activity is highly dynamic.MethodsTo address this, we analyzed the dynamic changes in intrahemispheric and interhemispheric connectivity patterns from 55 AUD patients and 32 healthy controls. The whole-brain functional connectivity was decomposed into ipsilateral and contralateral components, and the voxel-wise intrahemispheric and interhemispheric dynamic functional connectivity density (dFCD) was calculated using a sliding window analysis. At the same time, the relationship between dFCD values in abnormal brain regions and clinical variables was conducted.ResultsOur findings revealed that, compared to the HCs, AUD patients exhibited abnormal global, interhemispheric and intrahemispheric dFCD in the caudate, insula, parietal lobe, and occipital lobe. Furthermore, the dFCD values of these abnormal brain regions correlated with the average alcohol consumption and the severity of alcohol addiction in the AUD group.ConclusionsThe results indicate that brain regions associated with the salience network, default mode network, and visual network exhibited intrahemispheric and interhemispheric abnormal functional connectivity. This study underscores that dynamic metrics can provide overlapping or complementary information alongside static metrics, contributing to a more comprehensive understanding of neural activity in AUD.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1531905/fullalcohol use disorderdynamic functional connectivity densityintrahemisphere connectionsinterhemisphere connectionsresting-state functional magnetic resonance imaging |
| spellingShingle | Bohui Mei Yarui Wei Longyao Ma Qiuying Tao Jinghan Dang Jieping Sun Mengzhe Zhang Yong Zhang Jingliang Cheng Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder Frontiers in Psychiatry alcohol use disorder dynamic functional connectivity density intrahemisphere connections interhemisphere connections resting-state functional magnetic resonance imaging |
| title | Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder |
| title_full | Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder |
| title_fullStr | Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder |
| title_full_unstemmed | Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder |
| title_short | Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder |
| title_sort | abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder |
| topic | alcohol use disorder dynamic functional connectivity density intrahemisphere connections interhemisphere connections resting-state functional magnetic resonance imaging |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1531905/full |
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