Changes in Choroidal Thickness of Healthy Children during Myopia Progression over 4 Years: Boramae Myopia Cohort Study Report 5
Objective: To investigate the relationship between choroidal thickness and myopia by analyzing change in choroidal thickness over time in children with myopia progression. Design: Retrospective cohort study. Participants: Children with myopia. Methods: Spherical equivalent (SE), axial length, and ch...
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Elsevier
2025-05-01
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| author | Jeong Hyun Lee, MD, MSc Joo Young Shin, MD, PhD Martha Kim, MD, PhD Kyoung Min Lee, MD, PhD Sohee Oh, PhD Seok Hwan Kim, MD, PhD Ho-Kyung Choung, MD, PhD Jeeyun Ahn, MD, PhD |
| author_facet | Jeong Hyun Lee, MD, MSc Joo Young Shin, MD, PhD Martha Kim, MD, PhD Kyoung Min Lee, MD, PhD Sohee Oh, PhD Seok Hwan Kim, MD, PhD Ho-Kyung Choung, MD, PhD Jeeyun Ahn, MD, PhD |
| author_sort | Jeong Hyun Lee, MD, MSc |
| collection | DOAJ |
| description | Objective: To investigate the relationship between choroidal thickness and myopia by analyzing change in choroidal thickness over time in children with myopia progression. Design: Retrospective cohort study. Participants: Children with myopia. Methods: Spherical equivalent (SE), axial length, and choroidal thickness were measured every 2 years during course of 4 years in children with myopia enrolled in a prospective cohort study. Choroidal thickness was evaluated at 13 points on the ETDRS grid, and its longitudinal changes as myopia progresses were analyzed. Patients were categorized into 2 subgroups: progression group (SE change ≤ −0.5 diopters [D] over 2 years) and stable group (SE change > −0.5 D over 2 years). Main Outcome Measures: Spherical equivalent of refractive errors, axial length, and choroidal thickness. Results: A total of 46 eyes from 23 participants were included, with a mean baseline age of 9.6 ± 1.7 years. The SE values at baseline, 2-year follow-up, and 4-year follow-up were −4.26 ± 2.34 D, −5.62 ± 2.45 D, and −8.67 ± 2.47 D, respectively, indicating an average myopia progression of 4.41 D over the 4-year period. During the initial 2 years, no significant thinning of choroidal thickness was observed at any of the 13 measured points. However, during the following 2 years, significant choroidal thinning was identified at 9 of the 13 points (P < 0.05). In the subgroup analysis of the subsequent 2 years, the progression group exhibited significant thinning at 8 points, while the stable group still showed no significant changes in choroidal thickness at any point. Conclusions: In the early phase of myopia progression within moderate degree, choroidal thickness remained unchanged. However, when progressed to high myopia, significant choroidal thinning occurred, specifically in the progression group. In contrast, the stable group maintained consistent choroidal thickness throughout the study. These results suggest that choroidal thinning in children varies according to the degree of myopia that develops. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. |
| format | Article |
| id | doaj-art-4d432520d7bf4c859d7d5accfd39d27e |
| institution | DOAJ |
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| language | English |
| publishDate | 2025-05-01 |
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| series | Ophthalmology Science |
| spelling | doaj-art-4d432520d7bf4c859d7d5accfd39d27e2025-08-20T02:54:50ZengElsevierOphthalmology Science2666-91452025-05-015310068810.1016/j.xops.2024.100688Changes in Choroidal Thickness of Healthy Children during Myopia Progression over 4 Years: Boramae Myopia Cohort Study Report 5Jeong Hyun Lee, MD, MSc0Joo Young Shin, MD, PhD1Martha Kim, MD, PhD2Kyoung Min Lee, MD, PhD3Sohee Oh, PhD4Seok Hwan Kim, MD, PhD5Ho-Kyung Choung, MD, PhD6Jeeyun Ahn, MD, PhD7Department of Ophthalmology, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South KoreaDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South KoreaDepartment of Ophthalmology, Sensory Organ Research Institute, Dongguk University Ilsan Hospital, Goyang, South KoreaDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South KoreaMedical Research Collaborating Center, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South KoreaThe One Seoul Eye Clinic, Seoul, South KoreaDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea; Ho-Kyung Choung, MD, PhD, Department of Ophthalmology, SMG-SNU Boramae Medical Center, 20, Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, South Korea.Department of Ophthalmology, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea; Correspondence: Jeeyun Ahn, MD, PhD, Department of Ophthalmology, SMG-SNU Boramae Medical Center, 20, Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, South Korea.Objective: To investigate the relationship between choroidal thickness and myopia by analyzing change in choroidal thickness over time in children with myopia progression. Design: Retrospective cohort study. Participants: Children with myopia. Methods: Spherical equivalent (SE), axial length, and choroidal thickness were measured every 2 years during course of 4 years in children with myopia enrolled in a prospective cohort study. Choroidal thickness was evaluated at 13 points on the ETDRS grid, and its longitudinal changes as myopia progresses were analyzed. Patients were categorized into 2 subgroups: progression group (SE change ≤ −0.5 diopters [D] over 2 years) and stable group (SE change > −0.5 D over 2 years). Main Outcome Measures: Spherical equivalent of refractive errors, axial length, and choroidal thickness. Results: A total of 46 eyes from 23 participants were included, with a mean baseline age of 9.6 ± 1.7 years. The SE values at baseline, 2-year follow-up, and 4-year follow-up were −4.26 ± 2.34 D, −5.62 ± 2.45 D, and −8.67 ± 2.47 D, respectively, indicating an average myopia progression of 4.41 D over the 4-year period. During the initial 2 years, no significant thinning of choroidal thickness was observed at any of the 13 measured points. However, during the following 2 years, significant choroidal thinning was identified at 9 of the 13 points (P < 0.05). In the subgroup analysis of the subsequent 2 years, the progression group exhibited significant thinning at 8 points, while the stable group still showed no significant changes in choroidal thickness at any point. Conclusions: In the early phase of myopia progression within moderate degree, choroidal thickness remained unchanged. However, when progressed to high myopia, significant choroidal thinning occurred, specifically in the progression group. In contrast, the stable group maintained consistent choroidal thickness throughout the study. These results suggest that choroidal thinning in children varies according to the degree of myopia that develops. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.http://www.sciencedirect.com/science/article/pii/S2666914524002240ChildrenChoroid thicknessMyopia |
| spellingShingle | Jeong Hyun Lee, MD, MSc Joo Young Shin, MD, PhD Martha Kim, MD, PhD Kyoung Min Lee, MD, PhD Sohee Oh, PhD Seok Hwan Kim, MD, PhD Ho-Kyung Choung, MD, PhD Jeeyun Ahn, MD, PhD Changes in Choroidal Thickness of Healthy Children during Myopia Progression over 4 Years: Boramae Myopia Cohort Study Report 5 Ophthalmology Science Children Choroid thickness Myopia |
| title | Changes in Choroidal Thickness of Healthy Children during Myopia Progression over 4 Years: Boramae Myopia Cohort Study Report 5 |
| title_full | Changes in Choroidal Thickness of Healthy Children during Myopia Progression over 4 Years: Boramae Myopia Cohort Study Report 5 |
| title_fullStr | Changes in Choroidal Thickness of Healthy Children during Myopia Progression over 4 Years: Boramae Myopia Cohort Study Report 5 |
| title_full_unstemmed | Changes in Choroidal Thickness of Healthy Children during Myopia Progression over 4 Years: Boramae Myopia Cohort Study Report 5 |
| title_short | Changes in Choroidal Thickness of Healthy Children during Myopia Progression over 4 Years: Boramae Myopia Cohort Study Report 5 |
| title_sort | changes in choroidal thickness of healthy children during myopia progression over 4 years boramae myopia cohort study report 5 |
| topic | Children Choroid thickness Myopia |
| url | http://www.sciencedirect.com/science/article/pii/S2666914524002240 |
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