Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B
Humoral immunity constitutes major defense mechanism against viral infections. However, the association of hepatic injury and B-cells population in chronic hepatitis B virus (HBV) carriers has not been studied well. In this study, fifty seven hepatitis B surface antigen (HBsAg) positive and HBeAg ne...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/896864 |
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| author | Ashraf Mohamadkhani Elnaz Naderi Masoud Sotoudeh Aezam Katoonizadeh Ghodratollah Montazeri Hossein Poustchi |
| author_facet | Ashraf Mohamadkhani Elnaz Naderi Masoud Sotoudeh Aezam Katoonizadeh Ghodratollah Montazeri Hossein Poustchi |
| author_sort | Ashraf Mohamadkhani |
| collection | DOAJ |
| description | Humoral immunity constitutes major defense mechanism against viral infections. However, the association of hepatic injury and B-cells population in chronic hepatitis B virus (HBV) carriers has not been studied well. In this study, fifty seven hepatitis B surface antigen (HBsAg) positive and HBeAg negative patients were studied to determine the expression of CD20, a cell surface marker expressed on B-cells, in liver biopsy sections using immunohistochemistry. The patients’ clinical data at the time of liver biopsy were acquired from their medical records. There was a significant association between log HBV DNA and both ALT (r=0.36, P=0.006) and histologic activity index (HAI) total score (r=0.3, P=0.02), respectively. The CD20 was expressed in all 57 liver biopsy samples with a submembranous and membranous staining pattern and its expression was significantly associated with HAI total score (r=0.32, P=0.01) and stage of fibrosis (r=0.31, P=0.02). The susceptible B lymphocytes to hepatitis B virus might be implicated in the development of immune mediated inflammation of HBV-induced hepatic injury. The present data also support that the liver is potentially one of the secondary lymphoid organs. |
| format | Article |
| id | doaj-art-4d375a36e6b34dfcaaff482e98a15831 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-4d375a36e6b34dfcaaff482e98a158312025-02-03T01:11:34ZengWileyInternational Journal of Inflammation2090-80402042-00992014-01-01201410.1155/2014/896864896864Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis BAshraf Mohamadkhani0Elnaz Naderi1Masoud Sotoudeh2Aezam Katoonizadeh3Ghodratollah Montazeri4Hossein Poustchi5Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Centre, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Avenue, Tehran 14117 13135, IranLiver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Centre, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Avenue, Tehran 14117 13135, IranLiver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Centre, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Avenue, Tehran 14117 13135, IranLiver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Centre, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Avenue, Tehran 14117 13135, IranLiver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Centre, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Avenue, Tehran 14117 13135, IranLiver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Centre, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Avenue, Tehran 14117 13135, IranHumoral immunity constitutes major defense mechanism against viral infections. However, the association of hepatic injury and B-cells population in chronic hepatitis B virus (HBV) carriers has not been studied well. In this study, fifty seven hepatitis B surface antigen (HBsAg) positive and HBeAg negative patients were studied to determine the expression of CD20, a cell surface marker expressed on B-cells, in liver biopsy sections using immunohistochemistry. The patients’ clinical data at the time of liver biopsy were acquired from their medical records. There was a significant association between log HBV DNA and both ALT (r=0.36, P=0.006) and histologic activity index (HAI) total score (r=0.3, P=0.02), respectively. The CD20 was expressed in all 57 liver biopsy samples with a submembranous and membranous staining pattern and its expression was significantly associated with HAI total score (r=0.32, P=0.01) and stage of fibrosis (r=0.31, P=0.02). The susceptible B lymphocytes to hepatitis B virus might be implicated in the development of immune mediated inflammation of HBV-induced hepatic injury. The present data also support that the liver is potentially one of the secondary lymphoid organs.http://dx.doi.org/10.1155/2014/896864 |
| spellingShingle | Ashraf Mohamadkhani Elnaz Naderi Masoud Sotoudeh Aezam Katoonizadeh Ghodratollah Montazeri Hossein Poustchi Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B International Journal of Inflammation |
| title | Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B |
| title_full | Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B |
| title_fullStr | Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B |
| title_full_unstemmed | Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B |
| title_short | Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B |
| title_sort | clinical feature of intrahepatic b lymphocytes in chronic hepatitis b |
| url | http://dx.doi.org/10.1155/2014/896864 |
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