The roles, signalling pathways and therapeutic implications of Apoc1 in cancer
Abstract The apolipoprotein C (Apoc) family comprises a group of low-molecular-weight proteins that are essential for modulating lipoprotein metabolism, primarily influencing lipid transport and metabolic pathways. Apoc1, a member of the Apoc family, is consistently overexpressed across various canc...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-05-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02313-9 |
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| author | Hao-Han Guo Qiang Guo Qun-Xian Zhang Dan Li Yan Lv |
| author_facet | Hao-Han Guo Qiang Guo Qun-Xian Zhang Dan Li Yan Lv |
| author_sort | Hao-Han Guo |
| collection | DOAJ |
| description | Abstract The apolipoprotein C (Apoc) family comprises a group of low-molecular-weight proteins that are essential for modulating lipoprotein metabolism, primarily influencing lipid transport and metabolic pathways. Apoc1, a member of the Apoc family, is consistently overexpressed across various cancers, significantly correlating with poor prognosis. The multifaceted role of Apoc1 includes promoting cancer progression by activating key signalling pathways such as epithelial-mesenchymal transition (EMT), mitogen-activated protein kinases (MAPK), STAT3 and WNT3 A. Additionally, Apoc1 contributes to the regulatory networks involving lncRNAs and miRNAs, thereby influencing cancer. This comprehensive review delineates Apoc1’s mechanisms within malignant tumours and assesses its prognostic implications for patients with cancer. The aim is to shed light on potential novel therapeutic strategies in oncology, potentially revolutionising patient care and thereby enhancing patient survival rates and quality of life. |
| format | Article |
| id | doaj-art-4d32427a45514cbb9d2c1bf9d51e5b7b |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-4d32427a45514cbb9d2c1bf9d51e5b7b2025-08-20T03:53:13ZengSpringerDiscover Oncology2730-60112025-05-0116111010.1007/s12672-025-02313-9The roles, signalling pathways and therapeutic implications of Apoc1 in cancerHao-Han Guo0Qiang Guo1Qun-Xian Zhang2Dan Li3Yan Lv4Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Zunyi Medical UniversityDepartment of Cardiothoracic Surgery, Taihe Hospital, Hubei University of MedicineDepartment of Cardiothoracic Surgery, Taihe Hospital, Hubei University of MedicineDepartment of Oncology, Taihe Hospital, Hubei University of MedicineDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital of Zunyi Medical UniversityAbstract The apolipoprotein C (Apoc) family comprises a group of low-molecular-weight proteins that are essential for modulating lipoprotein metabolism, primarily influencing lipid transport and metabolic pathways. Apoc1, a member of the Apoc family, is consistently overexpressed across various cancers, significantly correlating with poor prognosis. The multifaceted role of Apoc1 includes promoting cancer progression by activating key signalling pathways such as epithelial-mesenchymal transition (EMT), mitogen-activated protein kinases (MAPK), STAT3 and WNT3 A. Additionally, Apoc1 contributes to the regulatory networks involving lncRNAs and miRNAs, thereby influencing cancer. This comprehensive review delineates Apoc1’s mechanisms within malignant tumours and assesses its prognostic implications for patients with cancer. The aim is to shed light on potential novel therapeutic strategies in oncology, potentially revolutionising patient care and thereby enhancing patient survival rates and quality of life.https://doi.org/10.1007/s12672-025-02313-9Apoc1CancerPrognosisEpithelial–mesenchymal transitionMitogen-activated protein kinases |
| spellingShingle | Hao-Han Guo Qiang Guo Qun-Xian Zhang Dan Li Yan Lv The roles, signalling pathways and therapeutic implications of Apoc1 in cancer Discover Oncology Apoc1 Cancer Prognosis Epithelial–mesenchymal transition Mitogen-activated protein kinases |
| title | The roles, signalling pathways and therapeutic implications of Apoc1 in cancer |
| title_full | The roles, signalling pathways and therapeutic implications of Apoc1 in cancer |
| title_fullStr | The roles, signalling pathways and therapeutic implications of Apoc1 in cancer |
| title_full_unstemmed | The roles, signalling pathways and therapeutic implications of Apoc1 in cancer |
| title_short | The roles, signalling pathways and therapeutic implications of Apoc1 in cancer |
| title_sort | roles signalling pathways and therapeutic implications of apoc1 in cancer |
| topic | Apoc1 Cancer Prognosis Epithelial–mesenchymal transition Mitogen-activated protein kinases |
| url | https://doi.org/10.1007/s12672-025-02313-9 |
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