Tobacco-related lung cancer burden in the Western Pacific Region from 1990 to 2021: An age-period-cohort analysis from the Global Burden of Disease Study
Introduction Lung cancer is a significant health issue in the Western Pacific region, where tobacco use is highly prevalent. This study examines the trends in tobacco-related lung cancer burden from 1990 to 2021, offering insights into the evolution of this critical public health challenge. Methods...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2025-03-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | https://www.tobaccoinduceddiseases.org/Tobacco-related-lung-cancer-burden-in-the-Western-Pacific-Region-from-1990-to-2021,201970,0,2.html |
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| Summary: | Introduction
Lung cancer is a significant health issue in the Western Pacific region,
where tobacco use is highly prevalent. This study examines the trends in tobacco-related
lung cancer burden from 1990 to 2021, offering insights into the evolution
of this critical public health challenge.
Methods
This study uses data from the Global Burden of Disease (GBD) 2021
study to analyze lung cancer rates. It employs an age-period-cohort analysis to
explore patterns in mortality and disability-adjusted life-years (DALYs) attributed
to tobacco-related lung cancer. The study also uses joinpoint regression analysis
to pinpoint changes over different periods.
Results
Our analyses revealed a substantial rise in both the number of deaths and
DALYs due to tobacco-related lung cancer in the Western Pacific region from
1990 to 2021. Total deaths increased by 163.42% to 644.5 thousand (95% UI:
517.9–793.8) in 2021, which is 2.6 times the global growth rate of 63.25%. While
global ASMR decreased by 25.46%, the Western Pacific Region showed minimal
change with a slight increase (AAPC=0.08). SDI analysis revealed an inverse
relationship with burden – for example, Singapore's ASMR decreased from 20.4
to 7.0 per 100000 population (high SDI) while China's increased from 23.8 to
25.8 (middle SDI). Age-period-cohort analysis showed the net drift of lung cancer
mortality was -0.16% per year. The fastest increase in ASMR occurred between
1998–2004 (APC=1.53%), followed by the steepest decline during 2004–2007
(APC= -1.49%).
Conclusions
The Western Pacific region continues to face a high burden of tobacco-related
lung cancer. |
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| ISSN: | 1617-9625 |