Immunophenotyping of Patients With Rheumatoid Arthritis Reveals Difference in CD27+IgD+ Unswitched Memory B Cell Profiles
Conclusion: Our results reveal, for the first time, that a reduced frequency of unswitched mB cells in patients with RA is the only significant abnormality distinguishing patients with RA from HC in a complex immunophenotyping panel of 72 different cell populations. This provides important informati...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/mi/9675331 |
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| author | Bérénice Hansen Raul Da Costa Dominique Revets Fanny Hedin Maria Konstantinou Eduardo Rosales Jubal Franck Ngangom Cédric C. Laczny Kirsten Roomp Viacheslav Petrov Andreas Michalsen Etienne Hanslian Daniela A. Koppold Anika Rajput Khokhar Nico Steckhan Michael Jeitler Brit Mollenhauer Sebastian Schade Michel Vaillant Antonio Cosma Paul Wilmes Jochen G. Schneider |
| author_facet | Bérénice Hansen Raul Da Costa Dominique Revets Fanny Hedin Maria Konstantinou Eduardo Rosales Jubal Franck Ngangom Cédric C. Laczny Kirsten Roomp Viacheslav Petrov Andreas Michalsen Etienne Hanslian Daniela A. Koppold Anika Rajput Khokhar Nico Steckhan Michael Jeitler Brit Mollenhauer Sebastian Schade Michel Vaillant Antonio Cosma Paul Wilmes Jochen G. Schneider |
| author_sort | Bérénice Hansen |
| collection | DOAJ |
| description | Conclusion: Our results reveal, for the first time, that a reduced frequency of unswitched mB cells in patients with RA is the only significant abnormality distinguishing patients with RA from HC in a complex immunophenotyping panel of 72 different cell populations. This provides important information to further individualize various interventions and possibly help to design novel therapeutic interventions. |
| format | Article |
| id | doaj-art-4d2f255957fb41a0bddd584613092d75 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4d2f255957fb41a0bddd584613092d752025-08-20T03:39:00ZengWileyMediators of Inflammation1466-18612025-01-01202510.1155/mi/9675331Immunophenotyping of Patients With Rheumatoid Arthritis Reveals Difference in CD27+IgD+ Unswitched Memory B Cell ProfilesBérénice Hansen0Raul Da Costa1Dominique Revets2Fanny Hedin3Maria Konstantinou4Eduardo Rosales Jubal5Franck Ngangom6Cédric C. Laczny7Kirsten Roomp8Viacheslav Petrov9Andreas Michalsen10Etienne Hanslian11Daniela A. Koppold12Anika Rajput Khokhar13Nico Steckhan14Michael Jeitler15Brit Mollenhauer16Sebastian Schade17Michel Vaillant18Antonio Cosma19Paul Wilmes20Jochen G. Schneider21Luxembourg Centre for Systems BiomedicineDepartment of Translational Medicine Operations Hub (TMOH)Department of Translational Medicine Operations Hub (TMOH)Department of Translational Medicine Operations Hub (TMOH)Department of Translational Medicine Operations Hub (TMOH)Department of Medical InformaticsDepartment of Medical InformaticsLuxembourg Centre for Systems BiomedicineLuxembourg Centre for Systems BiomedicineLuxembourg Centre for Systems BiomedicineEpidemiology and Health EconomicsEpidemiology and Health EconomicsEpidemiology and Health EconomicsDepartment of DermatologyEpidemiology and Health EconomicsEpidemiology and Health EconomicsDepartment of NeurologyDepartment of NeurologyDepartment of Medical InformaticsDepartment of Translational Medicine Operations Hub (TMOH)Luxembourg Centre for Systems BiomedicineLuxembourg Centre for Systems BiomedicineConclusion: Our results reveal, for the first time, that a reduced frequency of unswitched mB cells in patients with RA is the only significant abnormality distinguishing patients with RA from HC in a complex immunophenotyping panel of 72 different cell populations. This provides important information to further individualize various interventions and possibly help to design novel therapeutic interventions.http://dx.doi.org/10.1155/mi/9675331 |
| spellingShingle | Bérénice Hansen Raul Da Costa Dominique Revets Fanny Hedin Maria Konstantinou Eduardo Rosales Jubal Franck Ngangom Cédric C. Laczny Kirsten Roomp Viacheslav Petrov Andreas Michalsen Etienne Hanslian Daniela A. Koppold Anika Rajput Khokhar Nico Steckhan Michael Jeitler Brit Mollenhauer Sebastian Schade Michel Vaillant Antonio Cosma Paul Wilmes Jochen G. Schneider Immunophenotyping of Patients With Rheumatoid Arthritis Reveals Difference in CD27+IgD+ Unswitched Memory B Cell Profiles Mediators of Inflammation |
| title | Immunophenotyping of Patients With Rheumatoid Arthritis Reveals Difference in CD27+IgD+ Unswitched Memory B Cell Profiles |
| title_full | Immunophenotyping of Patients With Rheumatoid Arthritis Reveals Difference in CD27+IgD+ Unswitched Memory B Cell Profiles |
| title_fullStr | Immunophenotyping of Patients With Rheumatoid Arthritis Reveals Difference in CD27+IgD+ Unswitched Memory B Cell Profiles |
| title_full_unstemmed | Immunophenotyping of Patients With Rheumatoid Arthritis Reveals Difference in CD27+IgD+ Unswitched Memory B Cell Profiles |
| title_short | Immunophenotyping of Patients With Rheumatoid Arthritis Reveals Difference in CD27+IgD+ Unswitched Memory B Cell Profiles |
| title_sort | immunophenotyping of patients with rheumatoid arthritis reveals difference in cd27 igd unswitched memory b cell profiles |
| url | http://dx.doi.org/10.1155/mi/9675331 |
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